Aging is not a barrier to muscle and redox adaptations: applying the repeated eccentric exercise model
- PMID: 23628501
- DOI: 10.1016/j.exger.2013.04.009
Aging is not a barrier to muscle and redox adaptations: applying the repeated eccentric exercise model
Abstract
Despite the progress of analytic techniques and the refinement of study designs, striking disagreement exists among studies regarding the influence of exercise on muscle function and redox homeostasis in the elderly. The repeated eccentric exercise model was applied to produce long-lasting and extensive changes in redox biomarkers and to reveal more effectively the potential effects of aging on redox homeostasis. Ten young (20.6±0.5 years) and ten elderly men (64.6±1.1 years) underwent an isokinetic eccentric exercise session, which was repeated after three weeks. Muscle function/damage indices (torque, range of movement, muscle soreness and creatine kinase) and redox biomarkers (F2-isoprostanes, protein carbonyls, glutathione, catalase, superoxide dismutase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, uric acid, bilirubin and albumin) were assessed in plasma, erythrocytes or urine pre-exercise, immediately post-exercise and at 2 and 4 days post-exercise. As expected, the elderly group exhibited oxidative stress in baseline compared to the young group. Extensive muscle damage and extensive alterations in redox homeostasis appeared after the first bout of eccentric exercise. Noteworthy, the redox responses were similar between the age groups despite their differences in baseline values. Likewise, both age groups demonstrated blunted alterations in muscle damage and redox homeostasis after the second bout of eccentric exercise indicating adaptations from the first bout of exercise. Elderly individuals seem to be well fitted to participate in demanding physical activities without suffering detrimental effects on skeletal muscle and/or disturbances on redox homeostasis. The repeated eccentric exercise model may be a useful and practical physiological tool to study redox biology in humans.
Keywords: Adaptation; Aging; Biomarkers; Redox biology; Skeletal muscle.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never!Biogerontology. 2015 Apr;16(2):249-64. doi: 10.1007/s10522-014-9546-8. Epub 2014 Dec 24. Biogerontology. 2015. PMID: 25537184 Review.
-
Lengthening our perspective: morphological, cellular, and molecular responses to eccentric exercise.Muscle Nerve. 2014 Feb;49(2):155-70. doi: 10.1002/mus.24077. Epub 2013 Dec 3. Muscle Nerve. 2014. PMID: 24030935 Review.
-
Comparison between glucose-6-phosphate dehydrogenase-deficient and normal individuals after eccentric exercise.Med Sci Sports Exerc. 2010 Jun;42(6):1113-21. doi: 10.1249/MSS.0b013e3181c67ecd. Med Sci Sports Exerc. 2010. PMID: 19997026
-
Intramuscular adaptations to eccentric exercise and antioxidant supplementation.Amino Acids. 2010 Jun;39(1):219-32. doi: 10.1007/s00726-009-0432-7. Epub 2009 Dec 5. Amino Acids. 2010. PMID: 19967420
-
Decreased blood oxidative stress after repeated muscle-damaging exercise.Med Sci Sports Exerc. 2007 Jul;39(7):1080-9. doi: 10.1249/mss.0b013e31804ca10c. Med Sci Sports Exerc. 2007. PMID: 17596775
Cited by
-
Associations of resistance training levels with low muscle mass: a nationwide cross-sectional study in Korea.Eur Rev Aging Phys Act. 2024 Mar 7;21(1):5. doi: 10.1186/s11556-024-00339-6. Eur Rev Aging Phys Act. 2024. PMID: 38454366 Free PMC article.
-
Non-Invasive Measurement of Exercise-Induced Oxidative Stress in Response to Physical Activity. A Systematic Review and Meta-Analysis.Antioxidants (Basel). 2021 Dec 17;10(12):2008. doi: 10.3390/antiox10122008. Antioxidants (Basel). 2021. PMID: 34943111 Free PMC article. Review.
-
Pre-Exercise Carbohydrate or Protein Ingestion Influences Substrate Oxidation but Not Performance or Hunger Compared with Cycling in the Fasted State.Nutrients. 2021 Apr 14;13(4):1291. doi: 10.3390/nu13041291. Nutrients. 2021. PMID: 33919779 Free PMC article. Clinical Trial.
-
Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors.Front Physiol. 2020 Jun 29;11:644. doi: 10.3389/fphys.2020.00644. eCollection 2020. Front Physiol. 2020. PMID: 32695010 Free PMC article.
-
Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial.Eur J Appl Physiol. 2020 Jul;120(7):1531-1540. doi: 10.1007/s00421-020-04385-7. Epub 2020 May 2. Eur J Appl Physiol. 2020. PMID: 32361773 Clinical Trial.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous