A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23
- PMID: 24097066
- DOI: 10.1038/ng.2779
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23
Abstract
Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I.
Similar articles
-
Association studies of TNFSF4, TNFAIP3 and FAM167A-BLK polymorphisms with primary Sjogren's syndrome in Han Chinese.J Hum Genet. 2013 Jul;58(7):475-9. doi: 10.1038/jhg.2013.26. Epub 2013 May 2. J Hum Genet. 2013. PMID: 23635951
-
Association of GTF2I and GTF2IRD1 polymorphisms with systemic lupus erythematosus in a Chinese Han population.Clin Exp Rheumatol. 2015 Sep-Oct;33(5):632-8. Epub 2015 Aug 31. Clin Exp Rheumatol. 2015. PMID: 26320362
-
Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.Hum Genet. 2016 Nov;135(11):1287-1294. doi: 10.1007/s00439-016-1716-0. Epub 2016 Aug 8. Hum Genet. 2016. PMID: 27503288
-
Genetics of Sjögren's syndrome.Clin Immunol. 2017 Sep;182:41-47. doi: 10.1016/j.clim.2017.04.018. Epub 2017 May 3. Clin Immunol. 2017. PMID: 28476436 Free PMC article. Review.
-
Genetics of systemic lupus erythematosus and Sjögren's syndrome: an update.Curr Opin Rheumatol. 2016 Sep;28(5):506-14. doi: 10.1097/BOR.0000000000000310. Curr Opin Rheumatol. 2016. PMID: 27227345 Review.
Cited by
-
Interactions between TNFAIP3, PTPN22, and TRAF1-C5 gene polymorphisms in patients with primary Sjögren's syndrome.Arch Rheumatol. 2024 Feb 1;39(1):60-70. doi: 10.46497/ArchRheumatol.2024.10108. eCollection 2024 Mar. Arch Rheumatol. 2024. PMID: 38774701 Free PMC article.
-
Association of endometriosis with Sjögren's syndrome: Genetic insights (Review).Int J Mol Med. 2024 Feb;53(2):20. doi: 10.3892/ijmm.2024.5344. Epub 2024 Jan 8. Int J Mol Med. 2024. PMID: 38186322 Free PMC article. Review.
-
Neuronal Gtf2i deletion alters mitochondrial and autophagic properties.Commun Biol. 2023 Dec 14;6(1):1269. doi: 10.1038/s42003-023-05612-5. Commun Biol. 2023. PMID: 38097729 Free PMC article.
-
TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes.Cell. 2023 Dec 7;186(25):5569-5586.e21. doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27. Cell. 2023. PMID: 38016469
-
The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR T+ Itpr3tf/J Mice through the Regulation of Signaling Pathways Relevant to T Cells.Int J Mol Sci. 2023 Nov 11;24(22):16218. doi: 10.3390/ijms242216218. Int J Mol Sci. 2023. PMID: 38003408 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous