Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
- PMID: 24192039
- PMCID: PMC3816614
- DOI: 10.7554/eLife.01202
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Abstract
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients. Increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjects. We also identified unique Prevotella genes that correlated with disease. Further, colonization of mice revealed the ability of P. copri to dominate the intestinal microbiota and resulted in an increased sensitivity to chemically induced colitis. This work identifies a potential role for P. copri in the pathogenesis of RA. DOI: http://dx.doi.org/10.7554/eLife.01202.001.
Keywords: arthritis; autoimmunity; inflammation; metagenomics; microbiome; rheumatoid.
Conflict of interest statement
The authors declare that no competing interests exist.
Figures
Comment in
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A gut feeling about arthritis.Elife. 2013 Nov 5;2:e01608. doi: 10.7554/eLife.01608. Elife. 2013. PMID: 24192040 Free PMC article.
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Microbiome: pro-inflammatory Prevotella?Nat Rev Microbiol. 2014 Jan;12(1):5. doi: 10.1038/nrmicro3180. Epub 2013 Nov 25. Nat Rev Microbiol. 2014. PMID: 24270843 No abstract available.
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Rheumatoid arthritis: Prevotella copri associated with new-onset untreated RA.Nat Rev Rheumatol. 2014 Jan;10(1):2. doi: 10.1038/nrrheum.2013.187. Epub 2013 Nov 26. Nat Rev Rheumatol. 2014. PMID: 24275964 No abstract available.
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