Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jan;42(Database issue):D358-63.
doi: 10.1093/nar/gkt1115. Epub 2013 Nov 13.

The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases

Sandra Orchard  1 , Mais Ammari, Bruno Aranda, Lionel Breuza, Leonardo Briganti, Fiona Broackes-Carter, Nancy H Campbell, Gayatri Chavali, Carol Chen, Noemi del-Toro, Margaret Duesbury, Marine Dumousseau, Eugenia Galeota, Ursula Hinz, Marta Iannuccelli, Sruthi Jagannathan, Rafael Jimenez, Jyoti Khadake, Astrid Lagreid, Luana Licata, Ruth C Lovering, Birgit Meldal, Anna N Melidoni, Mila Milagros, Daniele Peluso, Livia Perfetto, Pablo Porras, Arathi Raghunath, Sylvie Ricard-Blum, Bernd Roechert, Andre Stutz, Michael Tognolli, Kim van Roey, Gianni Cesareni, Henning Hermjakob
Affiliations

The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases

Sandra Orchard et al. Nucleic Acids Res. 2014 Jan.

Abstract

IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate levels of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium (http://www.imexconsortium.org).

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The web-based IntAct curation environment is used by currently 11 independent organizations, most of which re-export the data and present it through their own web interfaces.
Figure 2.
Figure 2.
Growth of the IntAct database.
See this image and copyright information in PMC

Similar articles

  • Towards a reproducible interactome: semantic-based detection of redundancies to unify protein-protein interaction databases.
    Melkonian M, Juigné C, Dameron O, Rabut G, Becker E. Melkonian M, et al. Bioinformatics. 2022 Mar 4;38(6):1685-1691. doi: 10.1093/bioinformatics/btac013. Bioinformatics. 2022. PMID: 35015827 Review.
  • The IntAct database: efficient access to fine-grained molecular interaction data.
    Del Toro N, Shrivastava A, Ragueneau E, Meldal B, Combe C, Barrera E, Perfetto L, How K, Ratan P, Shirodkar G, Lu O, Mészáros B, Watkins X, Pundir S, Licata L, Iannuccelli M, Pellegrini M, Martin MJ, Panni S, Duesbury M, Vallet SD, Rappsilber J, Ricard-Blum S, Cesareni G, Salwinski L, Orchard S, Porras P, Panneerselvam K, Hermjakob H. Del Toro N, et al. Nucleic Acids Res. 2022 Jan 7;50(D1):D648-D653. doi: 10.1093/nar/gkab1006. Nucleic Acids Res. 2022. PMID: 34761267 Free PMC article.
  • The MIntAct Project and Molecular Interaction Databases.
    Licata L, Orchard S. Licata L, et al. Methods Mol Biol. 2016;1415:55-69. doi: 10.1007/978-1-4939-3572-7_3. Methods Mol Biol. 2016. PMID: 27115627
  • The IntAct molecular interaction database in 2012.
    Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, Duesbury M, Dumousseau M, Feuermann M, Hinz U, Jandrasits C, Jimenez RC, Khadake J, Mahadevan U, Masson P, Pedruzzi I, Pfeiffenberger E, Porras P, Raghunath A, Roechert B, Orchard S, Hermjakob H. Kerrien S, et al. Nucleic Acids Res. 2012 Jan;40(Database issue):D841-6. doi: 10.1093/nar/gkr1088. Epub 2011 Nov 24. Nucleic Acids Res. 2012. PMID: 22121220 Free PMC article.
  • MINT: a Molecular INTeraction database.
    Zanzoni A, Montecchi-Palazzi L, Quondam M, Ausiello G, Helmer-Citterich M, Cesareni G. Zanzoni A, et al. FEBS Lett. 2002 Feb 20;513(1):135-40. doi: 10.1016/s0014-5793(01)03293-8. FEBS Lett. 2002. PMID: 11911893 Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. The UniProt Consortium. (2013) Update on activities at the Universal Protein Resource (UniProt) in 2013. Nucleic Acids Res., 41, D43–D47. - PMC - PubMed
    1. Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, Duesbury M, Dumousseau M, Feuermann M, Hinz U, et al. The IntAct molecular interaction database in 2012. Nucleic Acids Res. 2013;41:D43–D47. - PMC - PubMed
    1. Saito R, Smoot ME, Ono K, Ruscheinski J, Wang PL, Lotia S, Pico AR, Bader GD, Ideker T. A travel guide to Cytoscape plugins. Nat. Methods. 2012;9:1069–1076. - PMC - PubMed
    1. Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, et al. Broadening the horizon—level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol. 2007;5:44. - PMC - PubMed
    1. del-Toro N, Dumousseau M, Orchard S, Jimenez RC, Galeota E, Launay G, Goll J, Breuer K, Ono K, Salwinski L, et al. A new reference implementation of the PSICQUIC web service. Nucleic Acids Res. 2013;41:W601–W606. - PMC - PubMed

Publication types

-