Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jun:54:47-52.
doi: 10.1016/j.exger.2013.12.009. Epub 2013 Dec 24.

Role of dendritic cells in innate and adaptive immune response in human aging

Sudhir Gupta  1
Affiliations
Review

Role of dendritic cells in innate and adaptive immune response in human aging

Sudhir Gupta. Exp Gerontol. 2014 Jun.

Abstract

Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs.

Keywords: IFN-I; IFN-III; NF-κB; T cell priming; mDC; pDC.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status.
    Brummelman J, Suárez-Hernández S, de Rond L, Bogaard-van Maurik M, Molenaar P, van Wijlen E, Oomen D, Beckers L, Rots NY, van Beek J, Nicolaie MA, van Els CACM, Boer MC, Kaaijk P, Buisman AM, de Wit J. Brummelman J, et al. Front Immunol. 2024 May 7;15:1392477. doi: 10.3389/fimmu.2024.1392477. eCollection 2024. Front Immunol. 2024. PMID: 38774878 Free PMC article.
  • Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke.
    Chen Q, Wu M, Tang Q, Yan P, Zhu L. Chen Q, et al. Aging Dis. 2024 May 7;15(3):1046-1074. doi: 10.14336/AD.2023.0721-1. Aging Dis. 2024. PMID: 37728582 Free PMC article. Review.
  • Gamma-Irradiated Non-Capsule Group B Streptococcus Promotes T-Cell Dependent Immunity and Provides a Cross-Protective Reaction.
    Zhi Y, Chen F, Cao G, Li F. Zhi Y, et al. Pharmaceuticals (Basel). 2023 Feb 20;16(2):321. doi: 10.3390/ph16020321. Pharmaceuticals (Basel). 2023. PMID: 37259463 Free PMC article.
  • Biomarkers of aging.
    Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Ci W, Ding BS, Ding Q, Gao F, Han JJ, Huang K, Ju Z, Kong QP, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun YE, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH. Aging Biomarker Consortium, et al. Sci China Life Sci. 2023 May;66(5):893-1066. doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11. Sci China Life Sci. 2023. PMID: 37076725 Free PMC article. Review.
  • "Just right" combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation.
    Ananya A, Holden KG, Gu Z, Nettleton D, Mallapragada SK, Wannemuehler MJ, Kohut ML, Narasimhan B. Ananya A, et al. Immun Ageing. 2023 Mar 9;20(1):10. doi: 10.1186/s12979-023-00332-0. Immun Ageing. 2023. PMID: 36895007 Free PMC article.
See all "Cited by" articles
-