Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: impact of sex and estrous cycle in rats
- PMID: 24464528
- DOI: 10.1007/s00213-014-3437-1
Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: impact of sex and estrous cycle in rats
Abstract
Rationale: Exercise has shown promise as an intervention for drug addiction; however, little is known regarding the exercise conditions that most effectively reduce relapse vulnerability and whether these conditions differ by sex.
Objective: Here, we examined sex differences in the dose-dependent effects of wheel running, an animal model of exercise, during abstinence on subsequent cocaine-seeking.
Methods: Male and female rats self-administered cocaine (1.5 mg/kg/infusion) under extended access conditions (24 h/day, 4 discrete trials/h) for 10 days. Rats were then given voluntary access to either an unlocked or locked running wheel for 1, 2, 6, or 24 h/day during the 14-day abstinence period. Separate groups of rats were housed in polycarbonate cages during abstinence to control for physical activity that the wheel may provide. Subsequent cocaine-seeking was assessed under a within-session extinction/cue-induced reinstatement procedure. Estrous cycle was monitored in females to determine whether the effectiveness of wheel running varied by estrous cycle phase.
Results: Although females ran more than males, males were more sensitive to the effects of running and showed a dose-dependent decrease in cocaine-seeking with longer access resulting in greater suppression. The dose-effect relationship was less straightforward in females and access to both a locked and unlocked wheel decreased cocaine-seeking with effects dependent on estrous cycle phase. Notably, extended (6 and 24 h/day), but not limited (1 and 2 h/day) access to a wheel surmounted the heightened vulnerability observed in females during estrus.
Conclusion: Taken together, our findings suggest that the effectiveness of wheel running is dose-, sex-, and estrous cycle-dependent.
Similar articles
-
Prevention of the incubation of cocaine seeking by aerobic exercise in female rats.Psychopharmacology (Berl). 2015 Oct;232(19):3507-13. doi: 10.1007/s00213-015-3999-6. Epub 2015 Jul 11. Psychopharmacology (Berl). 2015. PMID: 26159456 Free PMC article.
-
Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats.Psychopharmacology (Berl). 2014 Sep;231(18):3787-98. doi: 10.1007/s00213-014-3513-6. Epub 2014 Mar 5. Psychopharmacology (Berl). 2014. PMID: 24595506 Free PMC article.
-
Sex differences in the effect of wheel running on subsequent nicotine-seeking in a rat adolescent-onset self-administration model.Psychopharmacology (Berl). 2014 Apr;231(8):1753-62. doi: 10.1007/s00213-013-3359-3. Epub 2013 Nov 24. Psychopharmacology (Berl). 2014. PMID: 24271035 Free PMC article.
-
Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats.Psychopharmacology (Berl). 2014 Apr;231(7):1305-14. doi: 10.1007/s00213-013-3321-4. Epub 2013 Oct 31. Psychopharmacology (Berl). 2014. PMID: 24173624
-
Effect of wheel-running during abstinence on subsequent nicotine-seeking in rats.Psychopharmacology (Berl). 2013 Jun;227(3):403-11. doi: 10.1007/s00213-012-2964-x. Epub 2013 Jan 31. Psychopharmacology (Berl). 2013. PMID: 23371488 Free PMC article.
Cited by
-
Impact of SMAASH-C, a novel nutritional supplement, on drug-seeking and toxicity in female and male rats.Transl Psychiatry. 2024 May 27;14(1):214. doi: 10.1038/s41398-024-02940-w. Transl Psychiatry. 2024. PMID: 38802366 Free PMC article.
-
Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.bioRxiv [Preprint]. 2024 Mar 8:2024.03.04.583431. doi: 10.1101/2024.03.04.583431. bioRxiv. 2024. PMID: 38496609 Free PMC article. Preprint.
-
Transcriptional Profile of Exercise-Induced Protection Against Relapse to Cocaine Seeking in a Rat Model.Biol Psychiatry Glob Open Sci. 2023 Feb 3;3(4):734-745. doi: 10.1016/j.bpsgos.2023.01.007. eCollection 2023 Oct. Biol Psychiatry Glob Open Sci. 2023. PMID: 37881559 Free PMC article.
-
Role of nucleus accumbens dopamine 2 receptors in motivating cocaine use in male and female rats prior to and following the development of an addiction-like phenotype.Front Pharmacol. 2023 Jul 26;14:1237990. doi: 10.3389/fphar.2023.1237990. eCollection 2023. Front Pharmacol. 2023. PMID: 37564182 Free PMC article.
-
Sex differences in the neuroadaptations associated with incubated cocaine-craving: A focus on the dorsomedial prefrontal cortex.Front Behav Neurosci. 2023 Jan 5;16:1027310. doi: 10.3389/fnbeh.2022.1027310. eCollection 2022. Front Behav Neurosci. 2023. PMID: 36688133 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous