[Endoplasmic reticulum stress and vascular endothelial cell apoptosis]
- PMID: 24581138
- DOI: 10.3881/j.issn.1000-503X.2014.01.019
[Endoplasmic reticulum stress and vascular endothelial cell apoptosis]
Abstract
Endoplasmic reticulum stress (ERS) is a new pathway of apoptosis following the discovery of death receptor signaling pathway and mitochondrial pathway. By activating the unfolded protein response (UPR), ERS can suspend protein synthesis, restore the endoplasmic reticulum homeostasis, and thus play a protective role for cells; however, if the inducing factors of ERS persist, ERS will continue to trigger C/EBP homologous protein, JNK, caspase, or other pathways to induce apoptosis. In addition, the injury and apoptosis of vascular endothelial cells are key links in various diseases and pathophysiologic processes, and research has also shown that vascular endothelial cell apoptosis is closely related with the ERS. Effective intervention of ERS may restrain apoptosis and protect the vascular endothelium. This article reviews the recent research advances in ERS and its role in vascular endothelial cell apoptosis.
Similar articles
-
Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis.Biomed Pharmacother. 2020 Jul;127:110200. doi: 10.1016/j.biopha.2020.110200. Epub 2020 May 14. Biomed Pharmacother. 2020. PMID: 32417688 Free PMC article.
-
[The progress of study about endoplasmic reticulum stress in glaucoma].Zhonghua Yan Ke Za Zhi. 2016 Mar;52(3):231-5. doi: 10.3760/cma.j.issn.0412-4081.2016.03.018. Zhonghua Yan Ke Za Zhi. 2016. PMID: 26979122 Review. Chinese.
-
Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase.Peptides. 2013 Oct;48:156-65. doi: 10.1016/j.peptides.2013.08.015. Epub 2013 Aug 29. Peptides. 2013. PMID: 23994559
-
The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins.Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29. Int J Biochem Cell Biol. 2013. PMID: 23032698
-
[Research of endoplasmic reticulum stress and cardiovascular diseases].Sheng Li Ke Xue Jin Zhan. 2011 Dec;42(6):419-22. Sheng Li Ke Xue Jin Zhan. 2011. PMID: 22363979 Review. Chinese.
Cited by
-
Shear stress induces human aortic endothelial cell apoptosis via interleukin‑1 receptor‑associated kinase 2‑induced endoplasmic reticulum stress.Mol Med Rep. 2017 Nov;16(5):7205-7212. doi: 10.3892/mmr.2017.7524. Epub 2017 Sep 19. Mol Med Rep. 2017. PMID: 28944871 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Research Materials