Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: a population-based study (CoLaus Study)
- PMID: 24594292
- DOI: 10.1016/j.cyto.2014.01.003
Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: a population-based study (CoLaus Study)
Erratum in
- Cytokine. 2014 Oct;69(2):298
Abstract
Pro-inflammatory cytokines and high-sensitive C-reactive protein (hs-CRP) are associated with increased risk for cardiovascular disease. Low-dose aspirin for CV prevention is reported to have anti-inflammatory effects. The aim of this study was to determine the association between pro-inflammatory cytokines and hs-CRP levels and low-dose aspirin use for cardiovascular prevention in a population-based cohort (CoLaus Study). We assessed blood samples in 6085 participants (3201 women) aged 35-75years. Medications' use and indications were recorded. Among aspirin users (n=1'034; 17%), overall low-dose users (351; 5.8%) and low-dose for cardiovascular prevention users (324; 5.3%) were selected for analysis. Pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α were assessed by a multiplex particle-based flow cytometric assay and hs-CRP by an immunometric assay. Cytokines and hs-CRP were presented in quartiles. Multivariate analysis adjusting for sex, age, smoking status, body mass index, diabetes mellitus and immunomodulatory drugs showed no association between cytokines and hs-CRP levels and low-dose aspirin use for cardiovascular prevention, either comparing the topmost vs. the three other quartiles (OR 95% CI, 0.84 (0.59-1.18), 1.03 (0.78-1.32), 1.10 (0.83-1.46), 1.00 (0.67-1.69) for IL-1β, IL-6, TNF-α and hs-CRP, respectively), or comparing the topmost quartile vs. the first one (OR 95% CI, 0.87 (0.60-1.26), 1.19 (0.79-1.79), 1.26 (0.86-1.84), 1.06 (0.67-1.69)). Low-dose aspirin use for cardiovascular prevention does not impact plasma pro-inflammatory cytokine and hs-CRP levels in a population-based cohort.
Keywords: Cardiovascular prevention; Cytokines; Low-dose aspirin; Population-based sample; hs-CRP.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
-
The effects of honey on pro- and anti-inflammatory cytokines: A narrative review.Phytother Res. 2021 Jul;35(7):3690-3701. doi: 10.1002/ptr.7066. Epub 2021 Mar 9. Phytother Res. 2021. PMID: 33751689 Review.
-
High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy.Int J Cardiol. 2013 Oct 15;168(6):5126-34. doi: 10.1016/j.ijcard.2013.07.113. Epub 2013 Aug 24. Int J Cardiol. 2013. PMID: 23978367 Review.
-
Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study).Obes Facts. 2012;5(5):734-44. doi: 10.1159/000345045. Epub 2012 Oct 23. Obes Facts. 2012. PMID: 23108472
-
Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).Clin Endocrinol (Oxf). 2013 Feb;78(2):232-41. doi: 10.1111/j.1365-2265.2012.04384.x. Clin Endocrinol (Oxf). 2013. PMID: 22409372
-
Association of statins with inflammatory cytokines: a population-based Colaus study.Atherosclerosis. 2011 Nov;219(1):253-8. doi: 10.1016/j.atherosclerosis.2011.07.117. Epub 2011 Aug 4. Atherosclerosis. 2011. PMID: 21855068
Cited by
-
Association of Inflammatory Biomarkers With Survival Among Patients With Stage III Colon Cancer.JAMA Oncol. 2023 Mar 1;9(3):404-413. doi: 10.1001/jamaoncol.2022.6911. JAMA Oncol. 2023. PMID: 36701146 Free PMC article.
-
Association between high-sensitivity-CRP and liver elastography and cardiac ischemic diseases in patients with fatty liver.J Family Med Prim Care. 2022 Sep;11(9):5495-5499. doi: 10.4103/jfmpc.jfmpc_2223_21. Epub 2022 Oct 14. J Family Med Prim Care. 2022. PMID: 36505545 Free PMC article.
-
Association between the Inflammatory Potential of Diet and Stress among Female College Students.Nutrients. 2020 Aug 10;12(8):2389. doi: 10.3390/nu12082389. Nutrients. 2020. PMID: 32785011 Free PMC article.
-
Use of Aspirin and Statins in Relation to Inflammation in Benign Prostate Tissue in the Placebo Arm of the Prostate Cancer Prevention Trial.Cancer Prev Res (Phila). 2020 Oct;13(10):853-862. doi: 10.1158/1940-6207.CAPR-19-0450. Epub 2020 Jun 24. Cancer Prev Res (Phila). 2020. PMID: 32581009 Free PMC article. Clinical Trial.
-
Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease.J Geriatr Cardiol. 2020 May;17(5):256-263. doi: 10.11909/j.issn.1671-5411.2020.05.003. J Geriatr Cardiol. 2020. PMID: 32547608 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous