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. 2014 Jan-Feb;76(6):48-54.

Correlation of arsenic exposure through drinking groundwater and urinary arsenic excretion among adults in Pakistan

Mubashir Ahmed, Zafar Fatmi, Arif Ali
  • PMID: 24645413

Correlation of arsenic exposure through drinking groundwater and urinary arsenic excretion among adults in Pakistan

Mubashir Ahmed et al. J Environ Health. 2014 Jan-Feb.

Abstract

Long-term exposure to arsenic has been associated with manifestation of skin lesions (melanosis/keratosis) and increased risk of internal cancers (lung/bladder). The objective of the study described here was to determine the relationship between exposure of arsenic through drinking groundwater and urinary arsenic excretion among adults > or =15 years of age living in Khairpur district, Pakistan. Total arsenic was determined in drinking groundwater and in spot urine samples of 465 randomly selected individuals through hydride generation-atomic absorption spectrometry. Spearman's rank correlation coefficient was calculated between arsenic in drinking groundwater and arsenic excreted in urine. The median arsenic concentration in drinking water was 2.1 microg/L (range: 0.1-350), and in urine was 28.5 microg/L (range: 0.1-848). Positive correlation was found between total arsenic in drinking water and in urine (r = .52, p < .01). Urinary arsenic may be used as a biomarker of arsenic exposure through drinking water.

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