Use of inhaled and oral corticosteroids in pregnancy and the risk of malformations or miscarriage
- PMID: 25515299
- DOI: 10.1111/bcpt.12367
Use of inhaled and oral corticosteroids in pregnancy and the risk of malformations or miscarriage
Abstract
Corticosteroids are potent anti-inflammatory and immunosuppressive drugs, which sometimes must be given to pregnant women. Corticosteroids have been suspected to be teratogenic for many years; however, there is conflicting evidence regarding the association. Based on a literature review of three databases, this MiniReview provides an overview of inhaled and oral corticosteroid use in pregnancy with specific emphasis on the association between use of corticosteroids during pregnancy and risk of miscarriage and congenital malformations in offspring. The use of corticosteroids among pregnant women ranged from 0.2% to 10% and increased nearly two times in recent years. Taken together, the evidence suggests that the use of corticosteroids in early pregnancy is not associated with an increased risk of congenital malformations overall or oral clefts in offspring; at the same time, published estimates are inconsistent. The use of inhaled corticosteroids was associated with a slightly increased risk of miscarriage, whereas the use of oral corticosteroids was not; however, confounding by indication could not be ruled out.
© 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
Similar articles
-
Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring.Am J Ther. 2014 Mar-Apr;21(2):73-80. doi: 10.1097/MJT.0b013e3182491e02. Am J Ther. 2014. PMID: 23011170
-
High doses of inhaled corticosteroids during the first trimester of pregnancy and congenital malformations.J Allergy Clin Immunol. 2009 Dec;124(6):1229-1234.e4. doi: 10.1016/j.jaci.2009.09.025. J Allergy Clin Immunol. 2009. PMID: 19910032
-
High-dose corticosteroid exposure and osteoporosis intervention in adults.Ann Allergy Asthma Immunol. 2006 Oct;97(4):497-501. doi: 10.1016/S1081-1206(10)60941-6. Ann Allergy Asthma Immunol. 2006. PMID: 17069105
-
Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?Can Fam Physician. 2004 Aug;50:1083-5. Can Fam Physician. 2004. PMID: 15455804 Free PMC article. Review.
-
Teratogenic potential of corticosteroids in humans.Teratology. 1995 Jan;51(1):45-6. doi: 10.1002/tera.1420510107. Teratology. 1995. PMID: 7597656 Review.
Cited by
-
Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs.Adv Exp Med Biol. 2023;1428:149-177. doi: 10.1007/978-3-031-32554-0_7. Adv Exp Med Biol. 2023. PMID: 37466773
-
Dexamethasone Suppresses Palatal Cell Proliferation through miR-130a-3p.Int J Mol Sci. 2021 Nov 18;22(22):12453. doi: 10.3390/ijms222212453. Int J Mol Sci. 2021. PMID: 34830336 Free PMC article.
-
Exposure to Infliximab During Pregnancy: Post-Marketing Experience.Drug Saf. 2020 Feb;43(2):147-161. doi: 10.1007/s40264-019-00881-8. Drug Saf. 2020. PMID: 31677004 Free PMC article.
-
Knowledge, attitudes, and practice regarding medication use in pregnant women in Southern Italy.PLoS One. 2018 Jun 19;13(6):e0198618. doi: 10.1371/journal.pone.0198618. eCollection 2018. PLoS One. 2018. PMID: 29920515 Free PMC article.
-
Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study.BMJ. 2017 Mar 6;356:j895. doi: 10.1136/bmj.j895. BMJ. 2017. PMID: 28264814 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical