Disease-specific alterations in the enteric virome in inflammatory bowel disease
- PMID: 25619688
- PMCID: PMC4312520
- DOI: 10.1016/j.cell.2015.01.002
Disease-specific alterations in the enteric virome in inflammatory bowel disease
Abstract
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
Copyright © 2015 Elsevier Inc. All rights reserved.
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Comment in
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IBD. Gut microbiota in IBD goes viral.Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):122. doi: 10.1038/nrgastro.2015.26. Epub 2015 Feb 10. Nat Rev Gastroenterol Hepatol. 2015. PMID: 25666643 No abstract available.
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The Enteric Virome in Inflammatory Bowel Disease.Gastroenterology. 2015 Oct;149(4):1120-1. doi: 10.1053/j.gastro.2015.08.022. Epub 2015 Aug 25. Gastroenterology. 2015. PMID: 26319032 Free PMC article. No abstract available.
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References
-
- Angelberger S, Reinisch W, Makristathis A, Lichtenberger C, Dejaco C, Papay P, Novacek G, Trauner M, Loy A, Berry D. Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation. The American Journal of Gastroenterology. 2013;108:1620–1630. - PubMed
-
- Basic M, Keubler LM, Buettner M, Achard M, Breves G, Schroder B, Smoczek A, Jorns A, Wedekind D, Zschemisch NH, et al. Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice. Inflammatory bowel diseases. 2014;20:431–443. - PubMed
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