Physical activity and its mechanistic effects on prostate cancer
- PMID: 25800589
- DOI: 10.1038/pcan.2015.9
Physical activity and its mechanistic effects on prostate cancer
Abstract
Beneficial effects of physical activity have been illustrated in numerous aspects of health. With the increasing incidence of prostate cancer and changes in physical activity of men, understanding the link between the two has important implications for changing this cancer burden. Both positive and negative associations between physical activity and prostate cancer have been previously demonstrated in observational epidemiological studies. Elucidating the biological mechanisms would lead to a better understanding of how physical activity influences the progression of prostate cancer. This review was undertaken to: (1) identify evidence in literature that demonstrates the effects of physical activity on skeletal muscle secretomes, (2) indicate the plausible signaling pathways these proteins might activate, and (3) identify evidence in literature that demonstrates the roles of the signaling pathways in prostate cancer progression and regression. We also discuss proposed biological mechanisms and signaling pathways by which physical activity may prevent the development and progression of prostate cancer. We discuss proteins involved in the normal and aberrant growth and development of the prostate gland that may be affected by physical activity. We further identify future directions for research, including a better understanding of the biological mechanisms, the need to standardize physical activity and identify mechanistic end points of physical activity that can then be correlated with outcomes.
Similar articles
-
Prostate cancer epidemiology.Arch Esp Urol. 2014 Jun;67(5):373-82. Arch Esp Urol. 2014. PMID: 24914835 Review. English, Spanish.
-
Implications of insulin-like growth factor-I for prostate cancer therapies.Int J Urol. 2009 Feb;16(2):161-7. doi: 10.1111/j.1442-2042.2008.02224.x. Epub 2008 Dec 5. Int J Urol. 2009. PMID: 19183230 Review.
-
Prostate inflammation and its potential impact on prostate cancer: a current review.J Cell Biochem. 2008 Apr 1;103(5):1344-53. doi: 10.1002/jcb.21536. J Cell Biochem. 2008. PMID: 17955503 Review.
-
The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer.J Steroid Biochem Mol Biol. 2004 Nov;92(4):237-53. doi: 10.1016/j.jsbmb.2004.10.002. Epub 2005 Jan 5. J Steroid Biochem Mol Biol. 2004. PMID: 15663987 Review.
-
Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study.Cancer Res. 2003 Dec 1;63(23):8542-8. Cancer Res. 2003. PMID: 14679023
Cited by
-
The Impact of Physical Activity on the Outcomes of Active Surveillance in Prostate Cancer Patients: A Scoping Review.Cancers (Basel). 2024 Feb 1;16(3):630. doi: 10.3390/cancers16030630. Cancers (Basel). 2024. PMID: 38339381 Free PMC article. Review.
-
A holistic approach to prostate cancer treatment: natural products as enhancers to a medically minded approach.Med Oncol. 2023 Oct 31;40(12):343. doi: 10.1007/s12032-023-02209-0. Med Oncol. 2023. PMID: 37906337 Review.
-
The "home-based exercise for breast and prostate cancer patients during treatment-a feasibility trial" (BENEFIT CA trial): rationale and methodological protocol.Pilot Feasibility Stud. 2023 Sep 26;9(1):165. doi: 10.1186/s40814-023-01393-0. Pilot Feasibility Stud. 2023. PMID: 37752564 Free PMC article.
-
Dietary omega-6/omega-3 fatty acids and risk of prostate cancer; Is there any potential interaction by organophosphate insecticides among the agricultural health study population.Cancer Epidemiol. 2023 Aug;85:102410. doi: 10.1016/j.canep.2023.102410. Epub 2023 Jul 4. Cancer Epidemiol. 2023. PMID: 37413804
-
Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis.Geroscience. 2024 Feb;46(1):817-840. doi: 10.1007/s11357-023-00806-5. Epub 2023 May 12. Geroscience. 2024. PMID: 37171559 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical