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Review
. 2015 Mar 26;161(1):119-132.
doi: 10.1016/j.cell.2015.03.008.

The hunger genes: pathways to obesity

Agatha A van der Klaauw  1 , I Sadaf Farooqi  2
Affiliations
Free article
Review

The hunger genes: pathways to obesity

Agatha A van der Klaauw et al. Cell. .
Free article

Abstract

The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions.

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