Cardiovascular disease and arsenic exposure in Inner Mongolia, China: a case control study
- PMID: 25889926
- PMCID: PMC4409992
- DOI: 10.1186/s12940-015-0022-y
Cardiovascular disease and arsenic exposure in Inner Mongolia, China: a case control study
Abstract
Background: Millions of people are at risk from the adverse effects of arsenic exposure through drinking water. Increasingly, non-cancer effects such as cardiovascular disease have been associated with drinking water arsenic exposures. However, most studies have been conducted in highly exposed populations and lacked individual measurements.
Objective: To evaluate the association between cardiovascular disease and well-water arsenic exposure.
Methods: We conducted a hospital based case control study in Inner Mongolia, China. Cases and controls were prospectively identified and enrolled from a large hospital in the Hangjin Hou area. Cases were patients diagnosed with cardiovascular disease and controls were patients free from cardiovascular disease, admitted for conditions unrelated to arsenic exposure. Water from the primary water source and toenail samples were collected from each subject and tested for inorganic arsenic.
Results: Arsenic exposures were moderate with mean and median arsenic exposures of 8.9 μg/L and 13.1 μg/L, respectively. A total of 298 cases and 275 controls were enrolled. The adjusted odds ratio (AOR) and corresponding 95% confidence interval (95% CI) for a 10 μg/L increase in water arsenic were 1.19 (95% CI: 1.03, 1.38). Compared to exposures less than 10 μg/L, the AOR for water arsenic exposures above 40 μg/L was 4.05 (95% CI: 1.1-14.99, p = 0.04). Nail arsenic above 1.38 μg/g was also associated with an increased risk of cardiovascular disease.
Conclusions: By using standardized case definitions and collecting individual measurements of arsenic, this study addressed several limitations of previous studies. The results provide further evidence of the association between cardiovascular disease and arsenic at moderate exposures.
Figures
Similar articles
-
Relationship between long-term exposure to low-level arsenic in drinking water and the prevalence of abnormal blood pressure.J Hazard Mater. 2013 Nov 15;262:1154-8. doi: 10.1016/j.jhazmat.2012.09.045. Epub 2012 Sep 26. J Hazard Mater. 2013. PMID: 23069333
-
Arsenic exposure is associated with pediatric pneumonia in rural Bangladesh: a case control study.Environ Health. 2015 Oct 23;14:83. doi: 10.1186/s12940-015-0069-9. Environ Health. 2015. PMID: 26497043 Free PMC article.
-
Arsenic exposure from drinking water and endothelial dysfunction in Bangladeshi adolescents.Environ Res. 2022 May 15;208:112697. doi: 10.1016/j.envres.2022.112697. Epub 2022 Jan 8. Environ Res. 2022. PMID: 35007543 Free PMC article.
-
[Studies on markers of exposure and early effect in areas with arsenic pollution: methods and results of the project SEpiAs. Epidemiological studies on population exposed to low-to-moderate arsenic concentration in drinking water].Epidemiol Prev. 2014 May-Aug;38(3-4 Suppl 1):14-24. Epidemiol Prev. 2014. PMID: 25115551 Review. Italian.
-
Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment.Toxicology. 2014 Sep 2;323:78-94. doi: 10.1016/j.tox.2014.06.008. Epub 2014 Jun 20. Toxicology. 2014. PMID: 24953689 Review.
Cited by
-
Arsenic Exposure in Well Water From the Perspective of Patients and Providers.J Prim Care Community Health. 2024 Jan-Dec;15:21501319241247984. doi: 10.1177/21501319241247984. J Prim Care Community Health. 2024. PMID: 38682480 Free PMC article.
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Non-Uniform Bioaccumulation of Lead and Arsenic in Two Remote Regions of the Human Heart's Left Ventricle: A Post-Mortem Study.Biomolecules. 2023 Aug 10;13(8):1232. doi: 10.3390/biom13081232. Biomolecules. 2023. PMID: 37627297 Free PMC article.
-
Effects of Sodium Arsenite on the Myocardial Differentiation in Mouse Embryonic Bodies.Toxics. 2023 Feb 1;11(2):142. doi: 10.3390/toxics11020142. Toxics. 2023. PMID: 36851018 Free PMC article.
-
Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.Int J Environ Res Public Health. 2022 Dec 4;19(23):16232. doi: 10.3390/ijerph192316232. Int J Environ Res Public Health. 2022. PMID: 36498305 Free PMC article.
References
-
- Chen CJ, Chuang YC, Lin TM, Wu HY. Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers. Cancer Res. 1985;45(11 Pt 2):5895–9. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical