Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels
- PMID: 26064893
- PMCID: PMC4433628
- DOI: 10.1155/2015/286051
Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels
Abstract
The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined with histopathological examination. Male albino Wistar rats (n = 40) were pretreated orally with Tualang honey (3 g/kg/day) for 45 days. Subcutaneous injection of ISO (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate transaminase (AST)), cTnI, serum TC, and TG levels. In addition, ISO-induced myocardial injury was confirmed by a significant increase in heart lipid peroxidation (LPO) products (TBARS) and a significant decrease in antioxidant enzymes (SOD, GPx, GRx, and GST). Pretreatment of ischemic rats with Tualang honey conferred significant protective effects on all of the investigated biochemical parameters. The biochemical findings were further confirmed by histopathological examination in both Tualang-honey-pretreated and ISO-treated hearts. The present study demonstrates that Tualang honey confers cardioprotective effects on ISO-induced oxidative stress by contributing to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.
Figures
Similar articles
-
Cardioprotective Effects of Honey and Its Constituent: An Evidence-Based Review of Laboratory Studies and Clinical Trials.Int J Environ Res Public Health. 2020 May 21;17(10):3613. doi: 10.3390/ijerph17103613. Int J Environ Res Public Health. 2020. PMID: 32455701 Free PMC article. Review.
-
Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review.Biomed Pharmacother. 2017 Oct;94:1145-1166. doi: 10.1016/j.biopha.2017.08.009. Epub 2017 Aug 17. Biomed Pharmacother. 2017. PMID: 28826162 Review.
-
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats.Biomed Res Int. 2016;2016:6437641. doi: 10.1155/2016/6437641. Epub 2016 May 17. Biomed Res Int. 2016. PMID: 27294126 Free PMC article.
-
Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats.J Ethnopharmacol. 2012 May 7;141(1):33-40. doi: 10.1016/j.jep.2012.01.011. Epub 2012 Feb 1. J Ethnopharmacol. 2012. PMID: 22366678
-
Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.Chem Biol Interact. 2009 May 15;179(2-3):118-24. doi: 10.1016/j.cbi.2008.12.012. Epub 2008 Dec 25. Chem Biol Interact. 2009. PMID: 19146839
Cited by
-
Network Pharmacology and Molecular Docking Analysis of Active Compounds in Tualang Honey against Atherosclerosis.Foods. 2023 Apr 25;12(9):1779. doi: 10.3390/foods12091779. Foods. 2023. PMID: 37174317 Free PMC article.
-
Physicochemical Characteristics and Bioactive Compounds of Different Types of Honey and Their Biological and Therapeutic Properties: A Comprehensive Review.Antibiotics (Basel). 2023 Feb 6;12(2):337. doi: 10.3390/antibiotics12020337. Antibiotics (Basel). 2023. PMID: 36830249 Free PMC article. Review.
-
Potential Therapeutic Benefits of Honey in Neurological Disorders: The Role of Polyphenols.Molecules. 2022 May 20;27(10):3297. doi: 10.3390/molecules27103297. Molecules. 2022. PMID: 35630774 Free PMC article. Review.
-
Optimization of substrate composition for pectinase production from Satkara (Citrus macroptera) peel using Aspergillus niger-ATCC 1640 in solid-state fermentation.Heliyon. 2021 Oct 5;7(10):e08133. doi: 10.1016/j.heliyon.2021.e08133. eCollection 2021 Oct. Heliyon. 2021. PMID: 34693058 Free PMC article.
-
Monofloral Honeys as a Potential Source of Natural Antioxidants, Minerals and Medicine.Antioxidants (Basel). 2021 Jun 25;10(7):1023. doi: 10.3390/antiox10071023. Antioxidants (Basel). 2021. PMID: 34202118 Free PMC article. Review.
References
-
- Radhiga T., Rajamanickam C., Senthil S., Pugalendi K. V. Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. Food and Chemical Toxicology. 2012;50(11):3971–3977. doi: 10.1016/j.fct.2012.07.067. - DOI - PubMed
-
- Mohanty I., Arya D. S., Dinda A., Talwar K. K., Joshi S., Gupta S. K. Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic & Clinical Pharmacology & Toxicology. 2004;94(4):184–190. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous