Six-year longitudinal course and outcomes of subtypes of depression
- PMID: 26294366
- DOI: 10.1192/bjp.bp.114.153098
Six-year longitudinal course and outcomes of subtypes of depression
Abstract
Background: Clinical and aetiological heterogeneity have impeded our understanding of depression.
Aims: To evaluate differences in psychiatric and somatic course between people with depression subtypes that differed clinically (severity) and aetiologically (melancholic v. atypical).
Method: Data from baseline, 2-, 4- and 6-year follow-up of The Netherlands Study of Depression and Anxiety were used, and included 600 controls and 648 people with major depressive disorder (subtypes: severe melancholic n = 308; severe atypical n = 167; moderate n = 173, established using latent class analysis).
Results: Those with the moderate subtype had a significantly better psychiatric clinical course than the severe melancholic and atypical subtype groups. Suicidal thoughts and anxiety persisted longer in those with the melancholic subtype. The atypical subtype group continued to have the highest body mass index and highest prevalence of metabolic syndrome during follow-up, although differences between groups became less pronounced over time.
Conclusions: Course trajectories of depressive subtypes mostly ran parallel to each other, with baseline severity being the most important differentiator in course between groups.
© The Royal College of Psychiatrists 2016.
Similar articles
-
Depressive subtypes in an elderly cohort identified using latent class analysis.J Affect Disord. 2017 Aug 15;218:123-130. doi: 10.1016/j.jad.2017.04.059. Epub 2017 Apr 26. J Affect Disord. 2017. PMID: 28472702
-
Stability and transitions of depressive subtypes over a 2-year follow-up.Psychol Med. 2012 Oct;42(10):2083-93. doi: 10.1017/S0033291712000141. Epub 2012 Feb 17. Psychol Med. 2012. PMID: 22340131
-
Melancholic and atypical major depression--connection between cytokines, psychopathology and treatment.Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jun 3;43:1-6. doi: 10.1016/j.pnpbp.2012.11.009. Epub 2012 Nov 28. Prog Neuropsychopharmacol Biol Psychiatry. 2013. PMID: 23200828
-
Inflammatory markers and cortisol parameters across depressive subtypes in an older cohort.J Affect Disord. 2018 Jul;234:54-58. doi: 10.1016/j.jad.2018.02.080. Epub 2018 Feb 27. J Affect Disord. 2018. PMID: 29522944 Review.
-
Novel Augmentation Strategies in Major Depression.Dan Med J. 2017 Apr;64(4):B5338. Dan Med J. 2017. PMID: 28385173 Review.
Cited by
-
Eating Attitudes, Stress, Anxiety, and Depression in Dietetic Students and Association with Body Mass Index and Body Fat Percent: A Cross-Sectional Study.Diseases. 2024 May 20;12(5):108. doi: 10.3390/diseases12050108. Diseases. 2024. PMID: 38785763 Free PMC article.
-
Weight Suppression and Risk for Childhood Psychiatric Disorders.Child Psychiatry Hum Dev. 2023 Oct 18. doi: 10.1007/s10578-023-01617-7. Online ahead of print. Child Psychiatry Hum Dev. 2023. PMID: 37853282
-
Towards a multilevel model of major depression: genes, immuno-metabolic function, and cortico-striatal signaling.Transl Psychiatry. 2023 May 19;13(1):171. doi: 10.1038/s41398-023-02466-7. Transl Psychiatry. 2023. PMID: 37208333 Free PMC article. Review.
-
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.Transl Psychiatry. 2023 Apr 19;13(1):129. doi: 10.1038/s41398-023-02412-7. Transl Psychiatry. 2023. PMID: 37076454 Free PMC article. Review.
-
Lack of bidirectional association between C-reactive protein and depressive symptoms in middle-aged and older adults: Results from a nationally representative prospective cohort study.Front Psychol. 2023 Feb 13;14:1095150. doi: 10.3389/fpsyg.2023.1095150. eCollection 2023. Front Psychol. 2023. PMID: 36860788 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous