doi: 10.1210/jcem-47-1-200.
Opiates, prolactin, and the dopamine receptor
- PMID: 263291
- DOI: 10.1210/jcem-47-1-200
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Opiates, prolactin, and the dopamine receptor
J Clin Endocrinol Metab.
1978 Jul.
Abstract
The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90-150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, aand bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.
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