Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring

doi:10.1016/j.reprotox.2015.12.007

. 2016 Jan:59:109-16.

doi: 10.1016/j.reprotox.2015.12.007. Epub 2015 Dec 29.

Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring

Xi Jin¹, Xiaoxian Tian², Zhen Liu¹, Hui Hu¹, Xiaohong Li³, Ying Deng¹, Nana Li⁴, Jun Zhu⁵

Affiliations

¹ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Laboratory of Molecular Epidemiology for Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.
² The Department of Ultrasound at Guangxi Maternity and Child Healthcare Hospital in Nanning, Guangxi, China.
³ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China.
⁴ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
⁵ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address: zhujun028@163.com.

PMID: 26743994
DOI: 10.1016/j.reprotox.2015.12.007

Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring

Xi Jin et al. Reprod Toxicol. 2016 Jan.

. 2016 Jan:59:109-16.

doi: 10.1016/j.reprotox.2015.12.007. Epub 2015 Dec 29.

Authors

Xi Jin¹, Xiaoxian Tian², Zhen Liu¹, Hui Hu¹, Xiaohong Li³, Ying Deng¹, Nana Li⁴, Jun Zhu⁵

Affiliations

¹ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Laboratory of Molecular Epidemiology for Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.
² The Department of Ultrasound at Guangxi Maternity and Child Healthcare Hospital in Nanning, Guangxi, China.
³ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China.
⁴ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
⁵ National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address: zhujun028@163.com.

PMID: 26743994
DOI: 10.1016/j.reprotox.2015.12.007

Abstract

Hair arsenic and cadmium from 339 women with congenital heart defect (CHD)-affected pregnancies (case women) and 333 women with normal live births (control women) in China were estimated using inductively coupled plasma mass spectrometry. The median levels of hair arsenic and cadmium in the case women were 98.30 (74.30-136.30)ng/g and 14.60 (8.30-32.50)ng/g, respectively, which were significantly higher than the levels in the control group (P<0.05). Arsenic concentrations ≥62.03ng/g were associated with increased risk for almost every CHD subtype, with a dose-response relationship. However, only the group with the highest cadmium levels (≥25.85ng/g) displayed an increased risk of CHDs (AOR 1.96; 95% CI 1.24-3.09), with a 2.81-fold increase found for the occurrence of conotruncal defects in their offspring. Furthermore, an interaction between arsenic and cadmium was observed. Our findings suggest that maternal exposure to arsenic and cadmium may be a significant risk factor for CHDs in offspring. Cadmium may have an enhancing effect on the association between arsenic and the risk of CHDs in offspring.

Keywords: Arsenic; Biomarker; Cadmium; Congenital heart defects; Hair; Maternal exposure.

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Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring

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Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring

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