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Review
. 2016 Jan;16(1):8.
doi: 10.1007/s11892-015-0695-1.

Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance

Thomas Reinehr  1
Affiliations
Review

Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance

Thomas Reinehr. Curr Diab Rep. 2016 Jan.

Abstract

Pediatricians increasingly diagnose the metabolic syndrome (MetS) in recent years to describe cardiovascular risk and to guide management of the obese child. However, there is an ongoing discussion about how to define the MetS in childhood and adolescence. Since insulin resistance-the major driver of MetS-is influenced by pubertal stage, it is questionable to use definitions for MetS in children and adolescents that do not take into account pubertal status. A metabolic healthy status in prepubertal stage does not predict a metabolic healthy status during puberty. Furthermore, cardiovascular risk factors improve at the end of puberty without treatment. However, having a uniform internationally accepted definition of the MetS for children and adolescents would be very helpful for the description of populations in different studies. Therefore, the concept of MetS has to be revisited under the influence of puberty stage.

Keywords: Definition; Intervention; Metabolic Syndrome; Obesity; Puberty.

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References

    1. Lancet. 2005 Apr 16-22;365(9468):1415-28 - PubMed
    1. Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):190-6 - PubMed
    1. Diabetes Care. 2013 Nov;36(11):3739-45 - PubMed
    1. N Engl J Med. 2002 Nov 7;347(19):1483-92 - PubMed
    1. Diabetes Metab Res Rev. 2013 Nov;29(8):631-5 - PubMed

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