[Pharmacokinetic Effect of Aikeqing Granule by Different Medication Ways on Zidovudine in HAART of Rats]
- PMID: 26882615
[Pharmacokinetic Effect of Aikeqing Granule by Different Medication Ways on Zidovudine in HAART of Rats]
Abstract
Objective: To study pharmacokinetic effect of Aikeqing Granule (AG) by different medication ways on zidovudine (AZT) in highly active antiretroviral therapy ( HAART) of rats.
Methods: Totally 36 rats were administered with corresponding medications by gastrogavage, group I [HAART: AZT 31.5 mg/kg +3TC 31.5 mg/kg + Efavirenz (EFV) 63.0 mg/kg], group II (HAART+AG525 mg/kg), group III (HAART and AG 525 mg/kg after a 2-h interval). Drug concentrations of AZT were determined by high performance liquid chromatography-mass spectroscopy (HPLC-MS) before HAART, and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12 h after HAART, respectively. Pharmacokinetic parameters [such as t1/2, Tmax, Cmax, AUCo-t, plasma clearance rate (CL)] were calculated by DAS2.0 Software.
Results: The-equation of linear regression of AZT was good, with the precision, coefficient of recovery, and stability definitely confirmed. AUC in group II and III was larger than that of group I. There was no statistical difference in t1/2, Tmax, Cmax, AUC0-12 h, or AUC0-∞ among groups (P > 0.05).
Conclusion: AG combined HAART could enhance the Cmax of AZT.
Similar articles
-
Influence of a herbal preparation on the pharmacokinetics of highly active antiretroviral therapy drugs in rats.Pak J Pharm Sci. 2020 Jan;33(1):49-52. Pak J Pharm Sci. 2020. PMID: 32122830
-
Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis.Toxicol Appl Pharmacol. 2008 Jan 15;226(2):206-11. doi: 10.1016/j.taap.2007.09.007. Epub 2007 Sep 18. Toxicol Appl Pharmacol. 2008. PMID: 17949768
-
[UPLC-MS/MS determination of tanshinone ⅡA, salvianolic acid B and ginsenoside Rg₁ in Fufang Danshen preparation in rat plasma and brain tissues].Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):580-586. doi: 10.19540/j.cnki.cjcmm.2017.0014. Zhongguo Zhong Yao Za Zhi. 2017. PMID: 28952268 Chinese.
-
A rapid and sensitive method for simultaneous determination of lamivudine and zidovudine in human serum by on-line solid-phase extraction coupled to liquid chromatography/tandem mass spectrometry detection.Rapid Commun Mass Spectrom. 2004;18(10):1147-55. doi: 10.1002/rcm.1446. Rapid Commun Mass Spectrom. 2004. PMID: 15150840 Clinical Trial.
-
Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV.Antivir Ther. 2007;12(5):695-703. Antivir Ther. 2007. PMID: 17713153 Review.