doi: 10.1126/science.aaf6116.
Epub 2016 Apr 10.
Zika virus impairs growth in human neurospheres and brain organoids
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- PMID: 27064148
- DOI: 10.1126/science.aaf6116
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Zika virus impairs growth in human neurospheres and brain organoids
Science.
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Abstract
Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.
Copyright © 2016, American Association for the Advancement of Science.
Comment in
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Techniques: Spinning organoids shed light on Zika.Nat Rev Neurosci. 2016 May 19;17(6):334-5. doi: 10.1038/nrn.2016.66. Nat Rev Neurosci. 2016. PMID: 27194600 No abstract available.
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