Epidemiologic characteristics, clinical manifestations, and risk factors of 139 patients with Ebola virus disease in western Sierra Leone
- PMID: 27317404
- DOI: 10.1016/j.ajic.2016.04.216
Epidemiologic characteristics, clinical manifestations, and risk factors of 139 patients with Ebola virus disease in western Sierra Leone
Abstract
Objective: We aimed to fully describe epidemiologic characteristics, clinical manifestations, and clinical outcomes of Ebola virus disease (EVD), as well as detect independent factors significantly associated with mortality of the disease.
Methods: One hundred thirty-nine confirmed EVD patients enrolled at the JUI Holding and Treatment Centre in western Sierra Leone between November 15, 2014, and January 18, 2015, and demographic and clinical data were retrospectively collected and analyzed.
Results: The median age of investigated patients was 29 years and 55.4% were women. Of them, 76 patients (54.7%) died and 63 patients (45.3%) were cured. Case fatality rate among male patients was higher than in female patients (69.4% vs 42.9%). Fatigue (82.0%), anorexia (70.5%), abdominal pain (59.7%), diarrhea (58.3%), vomiting (56.1%), fever (55.4%), and muscle pain (54.0%) were the most common symptoms. In addition, 55.4% of investigated patients reported fever. Bleeding was seen in 10.8% of patients.
Conclusions: Our data show that mortality of EVD is associated with an older age, fever, and probably hiccups.
Keywords: Clinical outcome; Prevention; Prognostic factor; Symptom.
Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Clinical Features of Patients With Ebola Virus Disease in Sierra Leone.Clin Infect Dis. 2015 Aug 15;61(4):491-5. doi: 10.1093/cid/civ319. Epub 2015 May 20. Clin Infect Dis. 2015. PMID: 25995207
-
Sociodemographic and clinical determinants of in-facility case fatality rate for 938 adult Ebola patients treated at Sierra Leone Ebola treatment center.BMC Infect Dis. 2020 Apr 21;20(1):293. doi: 10.1186/s12879-020-04994-9. BMC Infect Dis. 2020. PMID: 32316923 Free PMC article.
-
Clinical features of suspected Ebola cases referred to the Moyamba ETC, Sierra Leone: challenges in the later stages of the 2014 outbreak.BMC Infect Dis. 2016 Jun 22;16:308. doi: 10.1186/s12879-016-1609-9. BMC Infect Dis. 2016. PMID: 27334891 Free PMC article.
-
Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone.Infect Dis Poverty. 2016 Nov 3;5(1):101. doi: 10.1186/s40249-016-0195-9. Infect Dis Poverty. 2016. PMID: 27806732 Free PMC article.
-
Inpatient signs and symptoms and factors associated with death in children aged 5 years and younger admitted to two Ebola management centres in Sierra Leone, 2014: a retrospective cohort study.Lancet Glob Health. 2016 Jul;4(7):e495-501. doi: 10.1016/S2214-109X(16)30097-3. Lancet Glob Health. 2016. PMID: 27340004
Cited by
-
Brief review on ebola virus disease and one health approach.Heliyon. 2023 Aug 8;9(8):e19036. doi: 10.1016/j.heliyon.2023.e19036. eCollection 2023 Aug. Heliyon. 2023. PMID: 37600424 Free PMC article. Review.
-
Non-human primate to human immunobridging demonstrates a protective effect of Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola.NPJ Vaccines. 2022 Nov 30;7(1):156. doi: 10.1038/s41541-022-00564-z. NPJ Vaccines. 2022. PMID: 36450746 Free PMC article.
-
Enterotoxigenic Escherichia coli Heat-Stable Toxin and Ebola Virus Delta Peptide: Similarities and Differences.Pathogens. 2022 Jan 27;11(2):170. doi: 10.3390/pathogens11020170. Pathogens. 2022. PMID: 35215114 Free PMC article. Review.
-
Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate.NPJ Vaccines. 2020 Dec 17;5(1):112. doi: 10.1038/s41541-020-00261-9. NPJ Vaccines. 2020. PMID: 33335092 Free PMC article.
-
Ebola virus disease.Nat Rev Dis Primers. 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. Nat Rev Dis Primers. 2020. PMID: 32080199 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
