Antioxidants from black and green tea: from dietary modulation of oxidative stress to pharmacological mechanisms
- PMID: 27747873
- PMCID: PMC5429329
- DOI: 10.1111/bph.13649
Antioxidants from black and green tea: from dietary modulation of oxidative stress to pharmacological mechanisms
Abstract
The consumption of tea (Camellia sinensis) has been correlated with a low incidence of chronic pathologies, such as cardiovascular disease and cancer, in which oxidative stress plays a critical role. Tea catechins and theaflavins are, respectively, the bioactive phytochemicals responsible for the antioxidant activity of green tea (GT) and black tea (BT). In addition to their redox properties, tea catechins and theaflavins could have also pharmacological activities, such as the ability to lower glucose, lipid and uric acid (UA) levels. These activities are mediated by pharmacological mechanisms such as enzymatic inhibition and interaction with transporters. Epigallocatechin gallate is the most active compound at inhibiting the enzymes involved in cholesterol and UA metabolism (hydroxy-3-methyl-glutaryl-CoA reductase and xanthine oxidase respectively) and affecting glucose transporters. The structural features of catechins that significantly contribute to their pharmacological effect are the presence/absence of the galloyl moiety and the number and positions of the hydroxyl groups on the rings. Although the inhibitory effects on α-glucosidase, maltase, amylase and lipase, multidrug resistance 1, organic anion transporters and proton-coupled folate transport occur at higher concentrations than those apparent in the circulation, these effects could be relevant in the gut. In conclusion, despite the urgent need for further research in humans, the regular consumption of moderate quantities of GT and BT can effectively modulate their antioxidant capacity, mainly in people subjected to oxidative stress, and could improve the metabolism of glucose, lipid and UA.
Linked articles: This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.
© 2016 The British Pharmacological Society.
Figures
Similar articles
-
Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats.Lipids Health Dis. 2018 Jul 18;17(1):157. doi: 10.1186/s12944-018-0808-3. Lipids Health Dis. 2018. PMID: 30021615 Free PMC article.
-
Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies.Food Chem. 2017 Feb 1;216:296-300. doi: 10.1016/j.foodchem.2016.08.052. Epub 2016 Aug 18. Food Chem. 2017. PMID: 27596423 Free PMC article.
-
Green tea polyphenols and their potential role in health and disease.Inflammopharmacology. 2015 Aug;23(4):151-61. doi: 10.1007/s10787-015-0236-1. Epub 2015 Jul 12. Inflammopharmacology. 2015. PMID: 26164000 Review.
-
Antioxidative properties of black tea.Prev Med. 2005 Jun;40(6):910-8. doi: 10.1016/j.ypmed.2004.10.014. Prev Med. 2005. PMID: 15850895 Review.
-
Theaflavins in black tea and catechins in green tea are equally effective antioxidants.J Nutr. 2001 Sep;131(9):2248-51. doi: 10.1093/jn/131.9.2248. J Nutr. 2001. PMID: 11533262
Cited by
-
Matcha Green Tea: Chemical Composition, Phenolic Acids, Caffeine and Fatty Acid Profile.Foods. 2024 Apr 11;13(8):1167. doi: 10.3390/foods13081167. Foods. 2024. PMID: 38672839 Free PMC article.
-
Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear.Heliyon. 2024 Feb 18;10(4):e26070. doi: 10.1016/j.heliyon.2024.e26070. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38420419 Free PMC article. Review.
-
Pumpkin and Pumpkin Byproducts: Phytochemical Constitutes, Food Application and Health Benefits.ACS Omega. 2023 Jun 23;8(26):23346-23357. doi: 10.1021/acsomega.3c02176. eCollection 2023 Jul 4. ACS Omega. 2023. PMID: 38170139 Free PMC article. Review.
-
Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds.Sci Rep. 2023 Nov 3;13(1):19020. doi: 10.1038/s41598-023-46181-1. Sci Rep. 2023. PMID: 37923923 Free PMC article.
-
Catechin Composition, Phenolic Content, and Antioxidant Properties of Commercially-Available Bagged, Gunpowder, and Matcha Green Teas.Plant Foods Hum Nutr. 2023 Dec;78(4):662-669. doi: 10.1007/s11130-023-01121-2. Epub 2023 Nov 3. Plant Foods Hum Nutr. 2023. PMID: 37923855 Free PMC article.
References
-
- Alemdaroglu NC, Dietz U, Wolffram S, Spahn‐Langguth H, Langguth P (2008). Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability. Biopharm Drug Dispos 29: 335–348. - PubMed
-
- Arts IC, van De Putte B, Hollman PC (2000). Catechin contents of foods commonly consumed in the Netherlands. 2. Tea, wine, fruit juices and chocolate milk. J Agric Food Chem 48: 1752–1757. - PubMed
-
- Aucamp J, Gaspar A, Hara Y, Apostolides Z (1997). Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis). Anticancer Res 17 (6D): 4381–4385. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous