Recent advances in the identification of the host factors involved in dengue virus replication
- PMID: 28124222
- PMCID: PMC6598876
- DOI: 10.1007/s12250-016-3902-6
Recent advances in the identification of the host factors involved in dengue virus replication
Abstract
Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
Keywords: dengue virus (DENV); host factors; miRNAs; proteins; replication.
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References
-
- Acosta EG, Castilla V, Damonte EB. Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis. J Gen Virol. 2008;89:474–484. - PubMed
-
- Acosta EG, Kumar A, Bartenschlager R. Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology. Adv Virus Res. 2014;88:1–109. - PubMed
-
- Agis-Juarez RA, Galvan I, Medina F, Daikoku T, Padmanabhan R, Ludert JE, del Angel RM. Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells. J Gen Virol. 2009;90:2893–2901. - PubMed
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