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. 2017 Apr:69:68-74.
doi: 10.1016/j.reprotox.2017.01.011. Epub 2017 Feb 2.

Low-level environmental metals and metalloids and incident pregnancy loss

Germaine M Buck Louis  1 , Melissa M Smarr  2 , Rajeshwari Sundaram  3 , Amy J Steuerwald  4 , Katherine J Sapra  5 , Zhaohui Lu  6 , Patrick J Parsons  7
Affiliations

Low-level environmental metals and metalloids and incident pregnancy loss

Germaine M Buck Louis et al. Reprod Toxicol. 2017 Apr.

Abstract

Environmental exposure to metals and metalloids is associated with pregnancy loss in some but not all studies. We assessed arsenic, cadmium, mercury, and lead concentrations in 501 couples upon trying for pregnancy and followed them throughout pregnancy to estimate the risk of incident pregnancy loss. Using Cox proportional hazard models, we estimated hazard ratios (HR) and 95% confidence intervals (CIs) for pregnancy loss after covariate adjustment for each partner modeled individually then we jointly modeled both partners' concentrations. Incidence of pregnancy loss was 28%. In individual partner models, the highest adjusted HRs were observed for female and male blood cadmium (HR=1.08; CI 0.81, 1.44; HR=1.09; 95% CI 0.84, 1.41, respectively). In couple based models, neither partner's blood cadmium concentrations were associated with loss (HR=1.01; 95% CI 0.75, 1.37; HR=0.92; CI 0.68, 1.25, respectively). We observed no evidence of a significant relation between metal(loids) at these environmentally relevant concentrations and pregnancy loss.

Keywords: Arsenic; Cadmium; Epidemiology; Lead; Mercury; Miscarriage; Pregnancy; Spontaneous abortion.

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Figures

Figure 1
Figure 1
Shape of the associations between the female’s and male partners’ blood metal concentrations and hazard of pregnancy loss - splines. Findings for female partners are presented in the left-sided figures, and those for males in the right-sided figures.
Figure 2
Figure 2
Shape of the associations between the female’s and male partners’ blood metal concentrations and hazard of pregnancy loss - splines. Findings for female partners are presented in the left-sided figures, and those for males in the right-sided figures.
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