Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease
- PMID: 28164449
- DOI: 10.1111/obr.12503
Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease
Abstract
Weight gain, obesity and diabetes have reached alarming levels in the developed world. Traditional risk factors such as over-eating, poor nutritional choices and lack of exercise cannot fully account for the high prevalence of metabolic disease. This review paper examines the scientific evidence on two novel risk factors that contribute to dys-regulated metabolic physiology: sleep disruption and circadian misalignment. Specifically, fundamental relationships between energy metabolism and sleep and circadian rhythms and the impact of sleep and circadian disruption on metabolic physiology are examined. Millions of individuals worldwide do not obtain sufficient sleep for healthy metabolic function, and many participate in shift work and social activities at times when the internal physiological clock is promoting sleep. These behaviours predispose an individual for poor metabolic health by promoting excess caloric intake in response to reduced sleep, food intake at internal biological times when metabolic physiology is not prepared, decreased energy expenditure when wakefulness and sleep are initiated at incorrect internal biological times, and disrupted glucose metabolism during short sleep and circadian misalignment. In addition to the traditional risk factors of poor diet and exercise, disturbed sleep and circadian rhythms represent modifiable risk factors for prevention and treatment of metabolic disease and for promotion of healthy metabolism.
Keywords: Circadian misalignment; sleep fragmentation; sleep loss; sleep restriction.
© 2017 World Obesity Federation.
Similar articles
-
The role of insufficient sleep and circadian misalignment in obesity.Nat Rev Endocrinol. 2023 Feb;19(2):82-97. doi: 10.1038/s41574-022-00747-7. Epub 2022 Oct 24. Nat Rev Endocrinol. 2023. PMID: 36280789 Free PMC article. Review.
-
Shift-work: is time of eating determining metabolic health? Evidence from animal models.Proc Nutr Soc. 2018 Aug;77(3):199-215. doi: 10.1017/S0029665117004128. Epub 2018 Jan 8. Proc Nutr Soc. 2018. PMID: 29307314 Review.
-
[On the detrimental metabolic impact of short, disturbed and erratic sleep].Dtsch Med Wochenschr. 2015 Aug;140(17):1278-83. doi: 10.1055/s-0041-103414. Epub 2015 Aug 25. Dtsch Med Wochenschr. 2015. PMID: 26306016 German.
-
Impact of circadian misalignment on energy metabolism during simulated nightshift work.Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17302-7. doi: 10.1073/pnas.1412021111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404342 Free PMC article.
-
Metabolic consequences of sleep and circadian disorders.Curr Diab Rep. 2014 Jul;14(7):507. doi: 10.1007/s11892-014-0507-z. Curr Diab Rep. 2014. PMID: 24816752 Free PMC article. Review.
Cited by
-
Association of sleep fragmentation with general and abdominal obesity: a population-based longitudinal study.Int J Obes (Lond). 2024 May 28. doi: 10.1038/s41366-024-01547-x. Online ahead of print. Int J Obes (Lond). 2024. PMID: 38806646
-
Assessment of workhour feeding practices, healthy behaviour score and body mass index of physicians in Northern Nigeria: a cross-sectional multi-centre study.J Prev Med Hyg. 2024 Mar 31;65(1):E73-E82. doi: 10.15167/2421-4248/jpmh2024.65.1.3171. eCollection 2024 Mar. J Prev Med Hyg. 2024. PMID: 38706772 Free PMC article.
-
Persistently short or long sleep duration increases the risk of sensory impairment in Chinese older adults.Front Public Health. 2024 Feb 29;12:1329134. doi: 10.3389/fpubh.2024.1329134. eCollection 2024. Front Public Health. 2024. PMID: 38487190 Free PMC article.
-
Interaction between adolescent sleep rhythms and gender in an obese population.World J Clin Cases. 2024 Jan 6;12(1):86-94. doi: 10.12998/wjcc.v12.i1.86. World J Clin Cases. 2024. PMID: 38292647 Free PMC article.
-
Associations of Training and Academic Stress with Sleep in Dual-Career Collegiate Badminton Athletes: A Preliminary Study.Nat Sci Sleep. 2024 Jan 24;16:43-52. doi: 10.2147/NSS.S432475. eCollection 2024. Nat Sci Sleep. 2024. PMID: 38283369 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical