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. 2017 Oct;36(5):482-495.
doi: 10.23736/S0392-9590.17.03824-X. Epub 2017 Mar 14.

Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2

Brian Lindegaard Pedersen  1 , Niels Bækgaard  2 , Bjørn Quistorff  3
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Free article

Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2

Brian Lindegaard Pedersen et al. Int Angiol. 2017 Oct.
Free article

Abstract

Background: This study elucidates the effects on muscle mitochondrial function in patients suffering from combined peripheral arterial disease (PAD) and type 2 diabetes (T2D) and the relation to patient symptoms and treatment.

Methods: Near infrared spectroscopy (NIRS) calf muscle exercise tests were conducted on 40 subjects, 15 (PAD), 15 (PAD+T2D) and 10 healthy age matched controls (CTRL) recruited from the vascular outpatient clinic at Gentofte County Hospital, Denmark. Calf muscle biopsies (~80 mg, gastrocnemius and anterior tibial muscles) were sampled and mitochondrial function tested applying high resolution oxygraphy on isolated muscle fibers.

Results: The NIRS exercise tests showed evidence of mitochondrial dysfunction in the PAD+T2D group by a longer recovery of the deoxygenation resulting from exercise in spite of a higher exercise oxygenation level compared to the PAD group. This was confirmed by a ~30% reduction in oxygen consumption in the muscle biopsy tests for the PAD+T2D compared to the PAD group (P<0.05). We claim that this mitochondrial dysfunction partly explains the ~30% reduction in tread mill walking distance for the PAD+T2D group observed in this study.

Conclusions: These findings support the use of early surgical revascularization in the PAD+T2D group, in order to obtain better walking performance and probably reduced risk of permanent mitochondrial damage.

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