The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering
- PMID: 28739653
- DOI: 10.1542/peds.2017-1603
The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering
Abstract
Metabolic syndrome (MetS) was developed by the National Cholesterol Education Program Adult Treatment Panel III, identifying adults with at least 3 of 5 cardiometabolic risk factors (hyperglycemia, increased central adiposity, elevated triglycerides, decreased high-density lipoprotein cholesterol, and elevated blood pressure) who are at increased risk of diabetes and cardiovascular disease. The constellation of MetS component risk factors has a shared pathophysiology and many common treatment approaches grounded in lifestyle modification. Several attempts have been made to define MetS in the pediatric population. However, in children, the construct is difficult to define and has unclear implications for clinical care. In this Clinical Report, we focus on the importance of screening for and treating the individual risk factor components of MetS. Focusing attention on children with cardiometabolic risk factor clustering is emphasized over the need to define a pediatric MetS.
Copyright © 2017 by the American Academy of Pediatrics.
Conflict of interest statement
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.
Similar articles
-
Metabolic syndrome, clustering of cardiovascular risk factors and high carotid intima-media thickness in children and adolescents.J Hypertens. 2020 Apr;38(4):618-624. doi: 10.1097/HJH.0000000000002318. J Hypertens. 2020. PMID: 31790055
-
Metabolic Syndrome in Children and Adolescents: Diagnostic Criteria, Therapeutic Options and Perspectives.Curr Obes Rep. 2019 Dec;8(4):472-479. doi: 10.1007/s13679-019-00357-x. Curr Obes Rep. 2019. PMID: 31691175 Review.
-
Clustering of Metabolic Risk Components and Associated Lifestyle Factors: A Nationwide Adolescent Study in Taiwan.Nutrients. 2019 Mar 9;11(3):584. doi: 10.3390/nu11030584. Nutrients. 2019. PMID: 30857325 Free PMC article.
-
Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014.Int J Cardiol. 2018 May 15;259:216-219. doi: 10.1016/j.ijcard.2018.01.139. Epub 2018 Feb 19. Int J Cardiol. 2018. PMID: 29472026
-
The metabolic syndrome.Endocr Rev. 2008 Dec;29(7):777-822. doi: 10.1210/er.2008-0024. Epub 2008 Oct 29. Endocr Rev. 2008. PMID: 18971485 Free PMC article. Review.
Cited by
-
Cardiorespiratory fitness attenuates the association between fatness and cardiometabolic risk in Chinese children.Front Endocrinol (Lausanne). 2024 May 15;15:1361447. doi: 10.3389/fendo.2024.1361447. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38812818 Free PMC article.
-
The Impact of Behavior Change Counseling Delivered via a Digital Health Tool Versus Routine Care Among Adolescents With Obesity: Pilot Randomized Feasibility Study.JMIR Form Res. 2024 May 17;8:e55731. doi: 10.2196/55731. JMIR Form Res. 2024. PMID: 38758581 Free PMC article.
-
Evaluating eight indicators for identifying metabolic syndrome in Chinese and American adolescents.Pediatr Res. 2024 May 14. doi: 10.1038/s41390-024-03247-8. Online ahead of print. Pediatr Res. 2024. PMID: 38745029
-
Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.Ital J Pediatr. 2024 Apr 19;50(1):75. doi: 10.1186/s13052-024-01634-9. Ital J Pediatr. 2024. PMID: 38637874 Free PMC article.
-
An Alternative Approach to Determining Metabolic Syndrome Component Cutoffs in Children and Adolescents Using Segmental Regression Analysis.Circ Rep. 2024 Mar 9;6(4):118-126. doi: 10.1253/circrep.CR-24-0007. eCollection 2024 Apr 10. Circ Rep. 2024. PMID: 38606414 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical