Nitric oxide bioavailability dysfunction involves in atherosclerosis
- PMID: 29091892
- DOI: 10.1016/j.biopha.2017.10.122
Nitric oxide bioavailability dysfunction involves in atherosclerosis
Abstract
The pathological characteristics of atherosclerosis (AS) include lipid accumulation, fibrosis formation and atherosclerotic plaque produced in artery intima, which leads to vascular sclerosis, lumen stenosis and irritates the ischemic changes of corresponding organs. Endothelial dysfunction was closely associated with AS. Nitric oxide (NO) is a multifunctional signaling molecule involved in the maintenance of metabolic and cardiovascular homeostasis. NO is also a potent endogenous vasodilator and enters for the key processes that suppresses the formation vascular lesion even AS. NO bioavailability indicates the production and utilization of endothelial NO in organisms, its decrease is related to oxidative stress, lipid infiltration, the expressions of some inflammatory factors and the alteration of vascular tone, which plays an important role in endothelial dysfunction. The enhancement of arginase activity and the increase in asymmetric dimethylarginine and hyperhomocysteinemia levels all contribute to AS by intervening NO bioavailability in human beings. Diabetes mellitus, obesity, chronic kidney disease and smoking, etc., also participate in AS by influencing NO bioavailability and NO level. Here, we reviewed the relationship between NO bioavailability and AS according the newest literatures.
Keywords: Atherosclerosis; Endothelial dysfunction; NO bioavailability; Nitric oxide; Nitric oxide synthase.
Copyright © 2017. Published by Elsevier Masson SAS.
Similar articles
-
Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy.Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):166-71. doi: 10.14797/mdcj-11-3-166. Methodist Debakey Cardiovasc J. 2015. PMID: 26634024 Free PMC article. Review.
-
Homocysteine-Induced Endothelial Dysfunction.Ann Nutr Metab. 2015;67(1):1-12. doi: 10.1159/000437098. Epub 2015 Jul 18. Ann Nutr Metab. 2015. PMID: 26201664 Review.
-
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.J Appl Physiol (1985). 2007 Jan;102(1):63-71. doi: 10.1152/japplphysiol.00660.2006. Epub 2006 Aug 31. J Appl Physiol (1985). 2007. PMID: 16946027
-
L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor.Altern Med Rev. 2005 Mar;10(1):14-23. Altern Med Rev. 2005. PMID: 15771559 Review.
-
The pivotal role of nitric oxide for vascular health.Can J Cardiol. 2004 Aug;20 Suppl B:7B-15B. Can J Cardiol. 2004. PMID: 15309199 Review.
Cited by
-
Therapeutic peptides for coronary artery diseases: in silico methods and current perspectives.Amino Acids. 2024 May 31;56(1):37. doi: 10.1007/s00726-024-03397-3. Amino Acids. 2024. PMID: 38822212 Free PMC article. Review.
-
Endothelial Reprogramming in Atherosclerosis.Bioengineering (Basel). 2024 Mar 27;11(4):325. doi: 10.3390/bioengineering11040325. Bioengineering (Basel). 2024. PMID: 38671747 Free PMC article. Review.
-
Potential Intersections between lncRNA, Vascular Cognitive Impairment, and Immunization Strategies: Insights and Future Directions.Vaccines (Basel). 2024 Feb 28;12(3):251. doi: 10.3390/vaccines12030251. Vaccines (Basel). 2024. PMID: 38543885 Free PMC article. Review.
-
Evaluation of serum nitric oxide synthase levels in patients with coronary slow flow based on corrected TIMI frame count.Arch Med Sci Atheroscler Dis. 2023 Dec 30;8:e140-e145. doi: 10.5114/amsad/176659. eCollection 2023. Arch Med Sci Atheroscler Dis. 2023. PMID: 38283932 Free PMC article.
-
Hypercholesterolemia exacerbates in-stent restenosis in rabbits: Studies of the mitigating effect of stent surface modification with a CD47-derived peptide.Atherosclerosis. 2024 Mar;390:117432. doi: 10.1016/j.atherosclerosis.2023.117432. Epub 2023 Dec 24. Atherosclerosis. 2024. PMID: 38241977
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials