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Review
. 2017 Nov 15;8(6):971-979.
doi: 10.3945/an.117.015628. Print 2017 Nov.

Cobalamin Status from Pregnancy to Early Childhood: Lessons from Global Experience

Rima Obeid  1 , Michelle Murphy  2   3 , Pol Solé-Navais  2 , Chittaranjan Yajnik  4
Affiliations
Review

Cobalamin Status from Pregnancy to Early Childhood: Lessons from Global Experience

Rima Obeid et al. Adv Nutr. .

Abstract

Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores (low or very low plasma cobalamin) will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation (from diet or supplements) is transferred to the child and is not likely to correct cobalamin status in depleted women. The prevalence of low cobalamin status is high especially in low-income settings or in populations with a low intake of animal products. Folate and cobalamin play interdependent roles in one-carbon metabolism. Although folic acid supplementation during early pregnancy is widely recommended and practiced, cobalamin supplementation during pregnancy and lactation has received little attention. Furthermore, the intake recommendations for pregnant and lactating women and in early life need reevaluation in the light of newly available evidence in the field.

Keywords: child development; cobalamin; cord blood; infants; lactation; pregnancy; recommended intake; supplementation.

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Conflict of interest statement

Author disclosures: RO, MM, PS-N, and CY, no conflicts of interest.

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References

    1. Rosenthal J, Lopez-Pazos E, Dowling NF, Pfeiffer CM, Mulinare J, Vellozzi C, Zhang M, Lavoie DJ, Molina R, Ramirez N, et al. . Folate and vitamin B12 deficiency among non-pregnant women of childbearing-age in guatemala 2009-2010: prevalence and identification of vulnerable populations. Matern Child Health J 2015;19:2272–85. - PMC - PubMed
    1. Samuel TM, Duggan C, Thomas T, Bosch R, Rajendran R, Virtanen SM, Srinivasan K, Kurpad AV. Vitamin B(12) intake and status in early pregnancy among urban South Indian women. Ann Nutr Metab 2013;62:113–22. - PMC - PubMed
    1. Duggan C, Srinivasan K, Thomas T, Samuel T, Rajendran R, Muthayya S, Finkelstein JL, Lukose A, Fawzi W, Allen LH, et al. . Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr 2014;144:758–64. - PMC - PubMed
    1. Hübner U, Alwan A, Jouma M, Tabbaa M, Schorr H, Herrmann W. Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women. Clin Chem Lab Med 2008;46:1265–9. - PubMed
    1. Candito M, Magnaldo S, Bayle J, Dor JF, Gillet Y, Bongain A, Van Obberghen E. Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss. Clin Chem Lab Med 2003;41:1026–7. - PubMed
-