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Review

Diazepam

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Diazepam

No authors listed.
Free Books & Documents

Excerpt

Diazepam is excreted into breastmilk and it and its active metabolite, nordiazepam, accumulate in the serum of breastfed infants with repeated doses. Because the half-life of diazepam and nordiazepam are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. A safety scoring system finds diazepam possible to use cautiously during breastfeeding.[1] One study found that a high dose of diazepam given during tubal ligation surgery increased the risk of infant weight loss and hyperbilirubinemia postoperatively. Other agents are preferred, especially while nursing a newborn or preterm infant. After a single dose of diazepam, as for sedation before a procedure or for a seizure, there is usually no need to wait to resume breastfeeding, although with a newborn or preterm infant, a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. During long-term use, monitor the infant for sedation, poor feeding and poor weight gain.

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References

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