Moclobemide
- PMID: 30000824
- Bookshelf ID: NBK501765
Moclobemide
Excerpt
Moclobemide is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Limited information indicates that maternal doses of moclobemide up to 900 mg daily produce low levels in milk. Although several breastfed infants apparently experienced no adverse effects during maternal use of moclobemide, no rigorous, long-term data are available. Until more data are available, moclobemide should only be used with careful monitoring during breastfeeding, especially while nursing a newborn or preterm infant.
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References
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- Taylor T, Kennedy D. Safety of moclobemide in pregnancy and lactation, four case reports. Birth Defects Res A Clin Mol Teratol. 2008;82:413. Abstract.
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- Juruena MF, Pires ML, Calil HM. Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake. Int Clin Psychopharmacol. 1997;12:317–21. - PubMed
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