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Review

Zuclopenthixol

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
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Review

Zuclopenthixol

No authors listed.
Free Books & Documents

Excerpt

Zuclopenthixol is not approved for marketing in the United States, by the U.S. Food and Drug Administration, but is available in other countries. Limited information indicates that maternal oral doses of up to 50 mg daily or depot injections of 72 mg every 2 weeks produce low levels in breastmilk and no detectable short-term adverse effects in the breastfed infants. No long-term data are available. One international guideline recommends that women taking zuclopenthixol not breastfeed.[1] However, a safety scoring system finds zuclopenthixol possible to use cautiously during breastfeeding.[2] Until more data are available, zuclopenthixol should be used with careful infant monitoring during breastfeeding.

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References

    1. Hasan A, Falkai P, Wobrock T, et al. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia. Part 3: Update 2015 management of special circumstances: Depression, suicidality, substance use disorders and pregnancy and lactation. World J Biol Psychiatry. 2015;16:142–70. - PubMed
    1. Uguz F. A new safety scoring system for the use of psychotropic drugs during lactation. Am J Ther. 2021;28:e118–e126. - PubMed
    1. Aaes-Jørgensen T, Bjørndal F, Bartels U. Zuclopenthixol levels in serum and breast milk. Psychopharmacology (Berl) 1986;90:417–8. - PubMed
    1. Matheson I, Skjaeraasen J. Milk concentrations of flupenthixol, nortriptyline and zuclopenthixol and between-breast differences in two patients. Eur J Clin Pharmacol. 1988;35:217–20. - PubMed

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