doi: 10.1016/0014-5793(87)81458-8.
Allopurinol and oxypurinol are hydroxyl radical scavengers
- PMID: 3030809
- DOI: 10.1016/0014-5793(87)81458-8
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Allopurinol and oxypurinol are hydroxyl radical scavengers
FEBS Lett.
.
Free article
Abstract
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 10(9) M-1 X s-1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k2 approx. 4 X 10(9) M-1 X s-1) and it also reacts with the myeloperoxidase-derived oxidant hypochlorous acid. Hence the protective actions of allopurinol against reperfusion damage after hypoxia need not be entirely due to xanthine oxidase inhibition.
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