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. 2019 Mar 29;11(4):736.
doi: 10.3390/nu11040736.

Difficulties in Translating Appetite Sensations Effect of Turmeric-Based Beverage When Given Prior to Isoenergetic Medium- or High-Fat Meals in Healthy Subjects

Yoghatama Cindya Zanzer  1   2 , Ângela Giovana Batista  3   4   5 , Anestis Dougkas  6   7 , Juscelino Tovar  8   9 , Yvonne Granfeldt  10 , Elin Östman  11   12
Affiliations

Difficulties in Translating Appetite Sensations Effect of Turmeric-Based Beverage When Given Prior to Isoenergetic Medium- or High-Fat Meals in Healthy Subjects

Yoghatama Cindya Zanzer et al. Nutrients. .

Abstract

The established effect of turmeric and its curcuminoids on appetite sensations was previously shown to be mediated by gut hormones release. In in vitro and preclinical studies, curcumin was shown to induce GLP-1 secretion and improve postprandial glycemia. In humans, consumption of 220 mL turmeric-based beverage (TUR, containing 185 mg gallic acid equivalents (GAE)) prior to white wheat bread (WWB, 50 g available carbohydrate) reduced early postprandial glucose levels and induced peptide tyrosine⁻tyrosine (PYY) release, as well as lowered 'desire to eat' and 'prospective consumption' in a postprandial setting, compared to control. In the present study, 12 healthy participants (5 men, 7 women) were admitted. An identical beverage was given and consumed prior to isoenergetic (423 kcal) medium-fat (MF) or high-fat (HF) meals. Appetite sensations including perceived 'hunger', 'desire to eat', 'satiety', 'fullness', 'prospective consumption', and 'thirst' were measured using visual analogue scales. MF induced 18% (p = 0.039) higher 'satiety' compared to HF. TUR consumption prior to either MF or HF did not modulate the perceived appetite sensations. Whether macronutrient-induced appetite sensations override the actual turmeric effects warrants further investigation.

Keywords: appetite; high fat; isoenergetic; medium fat; postprandial; turmeric.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic representation of the study design.
Figure 2
Figure 2
Postprandial response in ‘hunger’ (A), ‘desire to eat’ (B), ‘satiety’ (C), ‘fullness’ (D), ‘prospective consumption’ (E), and ‘thirst’ (F) after either control beverage + medium fat (MF), turmeric-based beverage + medium fat (MF-TUR), control beverage + high fat (HF), turmeric-based beverage + high fat (HF-TUR) in healthy subjects (LSMs ± SEM), n = 12.
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