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Randomized Controlled Trial
. 2020 Mar;45(3):275-282.
doi: 10.1139/apnm-2019-0116. Epub 2019 Jul 31.

Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women

Naima Atalhi  1 , Asmaa El Hamdouchi  1 , Amina Barkat  2 , Khalid Elkari  1 , Abdeslam Hamrani  1 , Mohammed El Mzibri  1 , Marjorie J Haskell  3 , Najat Mokhtar  1 , Hassan Aguenaou  1
Affiliations
Randomized Controlled Trial

Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women

Naima Atalhi et al. Appl Physiol Nutr Metab. 2020 Mar.

Abstract

In Morocco, postpartum women systematically receive a single, high dose of vitamin A (VA; 200 000 IU) within the first month of giving birth and vegetable oil is fortified to increase the VA intake. The efficacy of this combined approach of supplementation and fortification for increasing maternal VA status during lactation is not known. The purpose of the study is to evaluate the effect of postpartum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 months after giving birth. Postpartum women aged 19-40 years received a VA supplement and thereafter were randomly assigned to one of two groups to receive weekly vitamin A fortified oil (FO) or non-fortified oil (NFO) for 6 months. Serum retinol concentration was higher in the FO group than in the NFO group at 6 months after giving birth (p < 0.0001). Milk retinol per gram fat at baseline did not differ by group; by 3 months after giving birth, milk retinol per gram fat was higher in the FO group than in the NFO group (p = 0.02) and remained higher throughout the 6 months (p < 0.0001). The combination of supplementation and fortification has a more sustained impact on milk retinol concentrations than supplementation alone, which did not have a sustained impact on milk VA concentrations. The fortification approach seems to be more effective for maintaining adequate milk VA concentrations among lactating Moroccan women. Fortification seems to be a long-term solution for the problem of VA deficiency, especially among women in low-income communities.

Keywords: enrichissement; fortification; huile; lactating women; milk retinol; mère allaitante; oil; rétinol de lait; supplementation; supplémentation; vitamin A; vitamine A.

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