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. 2019 Nov 7:2019:3085827.
doi: 10.1155/2019/3085827. eCollection 2019.

Epidemiological and Clinical Features of Dengue Infection in Adults in the 2017 Outbreak in Vietnam

Bui Vu Huy  1 , Le Nguyen Minh Hoa  2 , Dang Thi Thuy  2 , Nguyen Van Kinh  2 , Ta Thi Dieu Ngan  1 , Le Van Duyet  2 , Nguyen Thanh Hung  3 , Ngo Ngoc Quang Minh  3 , Nguyen Thanh Truong  4 , Nguyen Van Vinh Chau  4
Affiliations

Epidemiological and Clinical Features of Dengue Infection in Adults in the 2017 Outbreak in Vietnam

Bui Vu Huy et al. Biomed Res Int. .

Abstract

Purpose: The clinical features and laboratory results of dengue-infected adult patients admitted to the hospital during the 2017 outbreak were analyzed in this study.

Method: This is a cross-sectional study. 2922 patients aged 18 years or more with dengue fever in National Hospital for Tropical Diseases (NHTD) in the North and Hospital for Tropical Disease (HTD) in the South of Vietnam were recruited in this study.

Result: Patients were admitted in the hospital around the year and concentrated from August to December, in 53/63 (84.0%) provinces in Vietnam, and patients in all ages were affected. The number of patients with dengue fever was 1675 (57.3%), dengue with warning signs 914 (31.3%), and severe dengue 333 (11.4%), respectively. Among patients with severe dengue, severe plasma leakage and dengue shock account for 238 (8.1%), severe organ impairment 73 (2.5%), and severe bleeding 22 (0.75%). The rate of mortality was 0.8%, and the outcome of dengue patients is worse in the elderly and people with underlying diseases.

Conclusion: The 2017 dengue outbreak occurred in a larger scale than in the previous years in terms of time, location, and number of patients. More elderly patients were infected by dengue in this outbreak, and this may contribute to the mortality rate. Clinical manifestations of dengue patients in Southern Vietnam are more typical than the northern, but the rate of severe dengue is not different. The mortality risk and underlying conditions associated with dengue-infected elderly patients are worthy of further investigations in the future.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Map of dengue outbreak 2017 in Vietnam. Hanoi (in the North) and Ho Chi Minh city (in the South) are highlighted in red with higher number of dengue cases than other provinces.
Figure 2
Figure 2
Variation of hematocrit according to days of illness in dengue patients.
Figure 3
Figure 3
Thrombocytopenia according to days of illness in dengue patients.
See this image and copyright information in PMC

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