Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation
- PMID: 31856585
- DOI: 10.1089/ars.2019.7975
Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation
Abstract
Significance: Nuclear factor kappa B (NF-κB) is a master regulator of the inflammatory response and represents a key regulatory node in the complex inflammatory signaling network. In addition, selective NF-κB transcriptional activity on specific target genes occurs through the control of redox-sensitive NF-κB interactions. Recent Advances: The selective NF-κB response is mediated by redox-modulated NF-κB complexes with ribosomal protein S3 (RPS3), Pirin (PIR). cAMP response element-binding (CREB)-binding protein (CBP)/p300, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), activator protein-1 (AP-1), signal transducer and activator of transcription 3 (STAT3), early growth response protein 1 (EGR-1), and SP-1. NF-κB is cooperatively coactivated with AP-1, STAT3, EGR-1, and SP-1 during the inflammatory process, whereas NF-κB complexes with CBP/p300 and PGC-1α regulate the expression of antioxidant genes. PGC-1α may act as selective repressor of phospho-p65 toward interleukin-6 (IL-6) in acute inflammation. p65 and nuclear factor erythroid 2-related factor 2 (NRF2) compete for binding to coactivator CBP/p300 playing opposite roles in the regulation of inflammatory genes. S-nitrosylation or tyrosine nitration favors the recruitment of specific NF-κB subunits to κB sites. Critical Issues: NF-κB is a redox-sensitive transcription factor that forms specific signaling complexes to regulate selectively the expression of target genes in acute inflammation. Protein-protein interactions with coregulatory proteins, other transcription factors, and chromatin-remodeling proteins provide transcriptional specificity to NF-κB. Furthermore, different NF-κB subunits may form distinct redox-sensitive homo- and heterodimers with distinct affinities for κB sites. Future Directions: Further research is required to elucidate the whole NF-κB interactome to fully characterize the complex NF-κB signaling network in redox signaling, inflammation, and cancer.
Keywords: NF-κB interactions; inflammation; redox signaling; signaling complexes.
Similar articles
-
Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis.J Pathol. 2019 Jan;247(1):48-59. doi: 10.1002/path.5166. Epub 2018 Dec 11. J Pathol. 2019. PMID: 30221360
-
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.Cell Signal. 2013 Oct;25(10):1939-48. doi: 10.1016/j.cellsig.2013.06.007. Epub 2013 Jun 11. Cell Signal. 2013. PMID: 23770291 Review.
-
Regulation of the MIR155 host gene in physiological and pathological processes.Gene. 2013 Dec 10;532(1):1-12. doi: 10.1016/j.gene.2012.12.009. Epub 2012 Dec 14. Gene. 2013. PMID: 23246696 Review.
-
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.Cell. 2007 Nov 30;131(5):927-39. doi: 10.1016/j.cell.2007.10.009. Cell. 2007. PMID: 18045535
-
The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene.J Biol Chem. 2003 Jan 3;278(1):651-60. doi: 10.1074/jbc.M204544200. Epub 2002 Oct 25. J Biol Chem. 2003. PMID: 12403783
Cited by
-
Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones.Cancers (Basel). 2024 Mar 8;16(6):1092. doi: 10.3390/cancers16061092. Cancers (Basel). 2024. PMID: 38539427 Free PMC article. Review.
-
The role of inflammation in silicosis.Front Pharmacol. 2024 Mar 7;15:1362509. doi: 10.3389/fphar.2024.1362509. eCollection 2024. Front Pharmacol. 2024. PMID: 38515835 Free PMC article. Review.
-
Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF-κB/MAPKs signaling pathway.Immun Inflamm Dis. 2024 Mar;12(3):e1215. doi: 10.1002/iid3.1215. Immun Inflamm Dis. 2024. PMID: 38488697 Free PMC article.
-
The role of circadian clock in regulating cell functions: implications for diseases.MedComm (2020). 2024 Mar 11;5(3):e504. doi: 10.1002/mco2.504. eCollection 2024 Mar. MedComm (2020). 2024. PMID: 38469551 Free PMC article. Review.
-
Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy.Diabetol Metab Syndr. 2024 Feb 26;16(1):49. doi: 10.1186/s13098-024-01282-3. Diabetol Metab Syndr. 2024. PMID: 38409074 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous