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. 2020 Dec;65(12):3551-3557.
doi: 10.1007/s10620-020-06069-w. Epub 2020 Jan 29.

Superoxide Dismutase Predicts Persistent Circulation Failure and Mortality in the Early Stage of Acute Pancreatitis

Xi Zheng  1   2 , Lei Li  1   2 , Yin Zhu  2 , Xin Huang  2 , Yue Zhang  1   2 , Bingjun Yu  1   2 , Wenhua He  3 , Nonghua Lv  2
Affiliations

Superoxide Dismutase Predicts Persistent Circulation Failure and Mortality in the Early Stage of Acute Pancreatitis

Xi Zheng et al. Dig Dis Sci. 2020 Dec.

Abstract

Objectives: Oxidative stress is an important event in the pathogenesis of acute pancreatitis. Superoxide dismutase is a major antioxidant enzyme in the body. The aim of this study was to investigate the changes in superoxide dismutase activity early in the onset of acute pancreatitis and its value in predicting the risk of organ failure and mortality.

Methods: Data for 2549 patients hospitalized from 2013 to 2017 were extracted from the prospective database, and we selected 854 adult patients who were admitted within 24 h of disease onset with complete data. Serum superoxide dismutase activities on the first, second, and third days of hospital admission for patients with different severities, organ failure, and mortality were compared. The areas under the curve for the prediction of organ failure, pancreatic necrosis, and mortality were estimated using receiver operating characteristic curves.

Results: Among the 854 adult patients, superoxide dismutase activities were significantly different among patients with mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis (P = 0.005). Superoxide dismutase activity was significantly decreased in patients with persistent renal failure (77.8 ± 37.2), persistent circulatory failure (66.2 ± 14.9), and mortality (64.3 ± 16.0). The accuracy of superoxide dismutase with regard to predicting persistent circulatory failure and mortality was high, and the areas under the receiver operating characteristic curves were 0.83 and 0.84, respectively.

Conclusions: Superoxide dismutase activity was negatively correlated with the severity and clinical outcome of AP. Superoxide dismutase activity is highly accurate at predicting persistent circulation failure and mortality in the early stage of AP.

Keywords: Acute pancreatitis; Mortality; Persistent circulation failure; Superoxide dismutase.

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References

    1. Sanfey H, Bulkley GB, Cameron JL. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann Surg. 1984;200:405–413. - DOI
    1. Kishimoto W, Nakao A, Nakano M, Takahashi A, Inaba H, Takagi H. Detection of superoxide free radicals in rats with acute pancreatitis. Pancreas. 1995;11:122–126. - DOI
    1. Shabanov VV, Sarbaeva NN, Milyakova MN. Generation of free oxygen radicals in the pathogenesis of experimental acute reflux pancreatitis. Bull Exp Biol Med. 2002;134:26–27. - DOI
    1. Gomez-Cambronero LG, Sabater L, Pereda J, et al. Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications. Curr Drug Targets Inflamm Allergy. 2002;1:393–403. - DOI
    1. Tadao M, Yuji O. Role of free radicals in the development of severe acute pancreatitis. Nihon Rinsho Jpn J Clin Med. 2004;62:2015–2020.

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