Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

doi:10.1038/s41392-020-0163-5

Multicenter Study

. 2020 May 5;5(1):62.

doi: 10.1038/s41392-020-0163-5.

Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

Dongze Li^#¹, You Chen^#², Hong Liu^#¹, Yu Jia¹, Fanghui Li¹, Wei Wang¹, Jiang Wu¹, Zhi Wan¹, Yu Cao¹, Rui Zeng^{3

4}

Affiliations

¹ Department of Emergency Medicine and Laboratory of Emergency Medicine, Deep Underground Space Medical Center, Disaster Medical Center, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.
² Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
³ Department of Emergency Medicine and Laboratory of Emergency Medicine, Deep Underground Space Medical Center, Disaster Medical Center, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China. zengrui_0524@126.com.
⁴ Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. zengrui_0524@126.com.

^# Contributed equally.

PMID: 32371949
PMCID: PMC7198844
DOI: 10.1038/s41392-020-0163-5

Multicenter Study

Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

Dongze Li et al. Signal Transduct Target Ther. 2020.

. 2020 May 5;5(1):62.

doi: 10.1038/s41392-020-0163-5.

Authors

Dongze Li^#¹, You Chen^#², Hong Liu^#¹, Yu Jia¹, Fanghui Li¹, Wei Wang¹, Jiang Wu¹, Zhi Wan¹, Yu Cao¹, Rui Zeng^{3

4}

Affiliations

¹ Department of Emergency Medicine and Laboratory of Emergency Medicine, Deep Underground Space Medical Center, Disaster Medical Center, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.
² Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
³ Department of Emergency Medicine and Laboratory of Emergency Medicine, Deep Underground Space Medical Center, Disaster Medical Center, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China. zengrui_0524@126.com.
⁴ Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. zengrui_0524@126.com.

^# Contributed equally.

PMID: 32371949
PMCID: PMC7198844
DOI: 10.1038/s41392-020-0163-5

No abstract available

Keywords: COVID-19; Immune dysfunction; Mortality; Organ injury.

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
a Discrimination of immunological profiling for mortality. b Discrimination of immunological profiling for multiple organ dysfunction syndromes

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References

1. Chen N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed
1. Qin, C. et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis.10.1093/cid/ciaa248 (2020). - PMC - PubMed
1. Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev.10.1093/nsr/nwaa041 (2020). - PMC - PubMed
1. National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. Diagnosis & Treatment Scheme for Novel Coronavirus Pneumonia (Trial) 6th Edition. http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aef....

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[1] Chen N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed

[2] Chen N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed

[3] Qin, C. et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis.10.1093/cid/ciaa248 (2020). - PMC - PubMed

[4] Qin, C. et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis.10.1093/cid/ciaa248 (2020). - PMC - PubMed

[5] Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev.10.1093/nsr/nwaa041 (2020). - PMC - PubMed

[6] Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev.10.1093/nsr/nwaa041 (2020). - PMC - PubMed

[7] National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. Diagnosis & Treatment Scheme for Novel Coronavirus Pneumonia (Trial) 6th Edition. http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aef....

[8] National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. Diagnosis & Treatment Scheme for Novel Coronavirus Pneumonia (Trial) 6th Edition. http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aef....

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Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

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Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

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