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Review
. 2020 Nov;34(11):2911-2920.
doi: 10.1002/ptr.6738. Epub 2020 Jun 23.

Potential effects of curcumin in the treatment of COVID-19 infection

Fatemeh Zahedipour  1 , Seyede Atefe Hosseini  1 , Thozhukat Sathyapalan  2 , Muhammed Majeed  3 , Tannaz Jamialahmadi  4   5   6 , Khalid Al-Rasadi  7 , Maciej Banach  8   9 , Amirhossein Sahebkar  9   10   11
Affiliations
Review

Potential effects of curcumin in the treatment of COVID-19 infection

Fatemeh Zahedipour et al. Phytother Res. 2020 Nov.

Abstract

Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.

Keywords: acute respiratory distress syndrome; curcuminoids; pulmonary fibrosis; viral infection.

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Conflict of interest statement

The authors have no other conflicting interests to disclose.

Figures

FIGURE 1
FIGURE 1
Multi‐site inhibitory effects of curcumin in the pathogenesis of COVID‐19 [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

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