Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis
- PMID: 32449782
- DOI: 10.2340/16501977-2694
Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis
Abstract
Objective: To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission.
Data sources: Ovid MEDLINE, EMBASE, CINAHL Plus, and PsycINFO were searched.
Study selection: Original studies reporting clinical outcomes of adult SARS and MERS survivors 3 months after admission or 2 months after discharge were included.
Data extraction: Studies were graded using the Oxford Centre for Evidence-Based Medicine 2009 Level of Evidence Tool. Meta-analysis was used to derive pooled estimates for prevalence/severity of outcomes up to 6 months after hospital discharge, and beyond 6 months after discharge.
Data synthesis: Of 1,169 identified studies, 28 were included in the analysis. Pooled analysis revealed that common complications up to 6 months after discharge were: impaired diffusing capacity for carbon monoxide (prevalence 27%, 95% confidence interval (CI) 15–45%); and reduced exercise capacity (mean 6-min walking distance 461 m, CI 450–473 m). The prevalences of post-traumatic stress disorder (39%, 95% CI 31–47%), depression (33%, 95% CI 20–50%) and anxiety (30%, 95% CI 10–61) beyond 6 months after discharge were considerable. Low scores on Short-Form 36 were identified beyond 6 months after discharge.
Conclusion: Lung function abnormalities, psychological impairment and reduced exercise capacity were common in SARS and MERS survivors. Clinicians should anticipate and investigate similar long-term outcomes in COVID-19 survivors.
Keywords: COVID-19; MERS, ARDS; SARS; anxiety; depression; exercise tolerance; fatigue; follow-up; follow-up studies; lung function; post-traumatic stress disorder; prevalence; quality of life; coronavirus infection.
Similar articles
-
Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic.Lancet Psychiatry. 2020 Jul;7(7):611-627. doi: 10.1016/S2215-0366(20)30203-0. Epub 2020 May 18. Lancet Psychiatry. 2020. PMID: 32437679 Free PMC article.
-
[Clinical features of coronavirus disease 2019 in children: a systemic review of severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019].Zhongguo Dang Dai Er Ke Za Zhi. 2020 Aug;22(8):844-853. doi: 10.7499/j.issn.1008-8830.2005172. Zhongguo Dang Dai Er Ke Za Zhi. 2020. PMID: 32800031 Free PMC article. Chinese.
-
Applying the WHO ICF Framework to the Outcome Measures Used in the Evaluation of Long-Term Clinical Outcomes in Coronavirus Outbreaks.Int J Environ Res Public Health. 2020 Sep 5;17(18):6476. doi: 10.3390/ijerph17186476. Int J Environ Res Public Health. 2020. PMID: 32899534 Free PMC article.
-
Coronavirus Disease 2019: Coronaviruses and Kidney Injury.J Urol. 2020 Nov;204(5):918-925. doi: 10.1097/JU.0000000000001289. Epub 2020 Jul 17. J Urol. 2020. PMID: 32693711 Review.
-
Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses.Phytother Res. 2021 Mar;35(3):1237-1247. doi: 10.1002/ptr.6888. Epub 2020 Dec 22. Phytother Res. 2021. PMID: 33350538 Review.
Cited by
-
Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia: A 6-month follow-up questionnaire study.World J Clin Cases. 2024 May 26;12(15):2560-2567. doi: 10.12998/wjcc.v12.i15.2560. World J Clin Cases. 2024. PMID: 38817225 Free PMC article.
-
Pulmonary Function, Computed Tomography Lung Abnormalities, and Small Airway Disease after COVID-19: 3-, 6-, and 9-Month Follow-Up.J Clin Med. 2024 May 7;13(10):2733. doi: 10.3390/jcm13102733. J Clin Med. 2024. PMID: 38792275 Free PMC article.
-
The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC).Pathogens. 2024 May 8;13(5):388. doi: 10.3390/pathogens13050388. Pathogens. 2024. PMID: 38787240 Free PMC article. Review.
-
Long-COVID autonomic syndrome in working age and work ability impairment.Sci Rep. 2024 May 23;14(1):11835. doi: 10.1038/s41598-024-61455-y. Sci Rep. 2024. PMID: 38782998 Free PMC article.
-
Long-term outcome of pulmonary involvement in patients with coronavirus disease 2019: The role of high-resolution computed tomography and functional status - A prospective single-center observational study.Ann Thorac Med. 2024 Apr-Jun;19(2):147-154. doi: 10.4103/atm.atm_191_23. Epub 2024 Apr 25. Ann Thorac Med. 2024. PMID: 38766376 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous