[Acute leukemia with translocation (8;16)]
- PMID: 3290841
[Acute leukemia with translocation (8;16)]
Abstract
Three cases of M5 acute leukemia, 1 with a t(8;16)(p11;p13), 2 with variant translocations, both with a breakpoint at band 8p11, t(6;8)(q27;p11) and t(8;19)(p11;q13) are reported and 12 other published cases reviewed. This is a rare new entity, of variable but rather poor prognosis, seen from birth to 75 years of age, with several cases in infants. Leukemic cells, which often show conspicuous phagocytic activity on bone marrow smears, bear both monocytic and granulocytic markers in at least some cases. The best therapeutic regimen is not well-defined. The molecular basis of the disorder remains to be elucidated.
Similar articles
-
Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia.Cancer Genet Cytogenet. 2006 Jul 15;168(2):146-9. doi: 10.1016/j.cancergencyto.2006.02.013. Cancer Genet Cytogenet. 2006. PMID: 16843104
-
Translocation (8;18;16)(p11;q21;p13). A new variant of t(8;16)(p11;p13) in acute monoblastic leukemia: case report and review of the literature.Cancer Genet Cytogenet. 2006 Feb;165(1):75-8. doi: 10.1016/j.cancergencyto.2005.10.017. Cancer Genet Cytogenet. 2006. PMID: 16490600 Review.
-
A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13)--case report and review of the literature.Leuk Res. 1995 Jun;19(6):367-79. doi: 10.1016/0145-2126(94)00150-9. Leuk Res. 1995. PMID: 7596149 Review.
-
Congenital acute monoblastic leukemia with double translocation (8;16) (p11;p13) and (16;20) (q13;p13).Nouv Rev Fr Hematol (1978). 1988;30(4):247-50. Nouv Rev Fr Hematol (1978). 1988. PMID: 3194189
-
A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis.Cancer Genet Cytogenet. 1989 Oct 1;42(1):67-73. doi: 10.1016/0165-4608(89)90009-5. Cancer Genet Cytogenet. 1989. PMID: 2790748
Cited by
-
A classification of acute leukaemia for the 1990s.Ann Hematol. 1991 Feb;62(1):16-21. doi: 10.1007/BF01714978. Ann Hematol. 1991. PMID: 2031964 Review.
Publication types
MeSH terms
LinkOut - more resources
Medical