Fitness and prostate cancer screening, incidence, and mortality: Results from the Henry Ford Exercise Testing (FIT) Project
- PMID: 33561293
- DOI: 10.1002/cncr.33426
Fitness and prostate cancer screening, incidence, and mortality: Results from the Henry Ford Exercise Testing (FIT) Project
Abstract
Background: The relation between cardiorespiratory fitness (CRF) and prostate cancer is not well established. The objective of this study was to determine whether CRF is associated with prostate cancer screening, incidence, or mortality.
Methods: The Henry Ford Exercise Testing Project is a retrospective cohort study of men aged 40 to 70 years without cancer who underwent physician-referred exercise stress testing from 1995 to 2009. CRF was quantified in metabolic equivalents of task (METs) (<6 [reference], 6-9, 10-11, and ≥12 METs), estimated from the peak workload achieved during a symptom-limited, maximal exercise stress test. Prostate-specific antigen (PSA) testing, incident prostate cancer, and all-cause mortality were analyzed with multivariable adjusted Poisson regression and Cox proportional hazard models.
Results: In total, 22,827 men were included, of whom 739 developed prostate cancer, with a median follow-up of 7.5 years. Men who had high fitness (≥12 METs) had an 28% higher risk of PSA screening (95% CI, 1.2-1.3) compared with those who had low fitness (<6 METs. After adjusting for PSA screening, fitness was associated with higher prostate cancer incidence (men aged <55 years, P = .02; men aged >55 years, P ≤ .01), but not with advanced prostate cancer. Among the men who were diagnosed with prostate cancer, high fitness was associated with a 60% lower risk of all-cause mortality (95% CI, 0.2-0.9).
Conclusions: Although men with high fitness are more likely to undergo PSA screening, this does not fully account for the increased incidence of prostate cancer seen among these individuals. However, men with high fitness have a lower risk of death after a prostate cancer diagnosis, suggesting that the cancers identified may be low-risk with little impact on long-term outcomes.
Keywords: cancer; cardiorespiratory fitness; prostate cancer; prostate-specific antigen.
© 2021 American Cancer Society.
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References
-
- Algotar AM, Cress A. Prostate cancer prevention. In: Alberts DS, Hess LM, eds. Fundamentals of Cancer Prevention. Springer International Publishing; 2019:607-628.doi:10.1007/978-3-030-15935-1_17
-
- Marshall CH, Al-Mallah MH, Dardari Z, et al. Cardiorespiratory fitness and incident lung and colorectal cancer in men and women: results from the Henry Ford Exercise Testing (FIT) cohort. Cancer. 2019;125:2594-2601.doi:10.1002/cncr.32085
-
- Robsahm TE, Falk RS, Heir T, et al. Cardiorespiratory fitness and risk of site-specific cancers: a long-term prospective cohort study. Cancer Med. 2017;6:865-873.doi:10.1002/cam4.1043
-
- Lakoski SG, Willis BL, Barlow CE, et al. Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in men: the Cooper Center Longitudinal Study. JAMA Oncol. 2015;1:231-237.doi:10.1001/jamaoncol.2015.0226
-
- Liu L, Shi Y, Li T, et al. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016;50:372-378.doi:10.1136/bjsports-2015-094728
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