Alveolar macrophage procoagulant activity is increased in acute hyperoxic lung injury
- PMID: 3358451
- PMCID: PMC1880588
Alveolar macrophage procoagulant activity is increased in acute hyperoxic lung injury
Abstract
Alveolar macrophage accumulation and interstitial fibrin deposition are prominent in adult respiratory distress syndrome and chronic interstitial lung diseases. The role of alveolar macrophages in the initiation of fibrin deposition and lung injury in these diseases is uncertain. Expression of procoagulant activity by these cells may provide evidence of macrophage activation and involvement in the initiation of lung fibrin deposition. An experimental model of hyperoxia-induced lung injury in rats was studied for assessment of the relationship of lung injury, fibrin deposition, and alveolar macrophage procoagulant activity. Lung injury was assessed histologically and functionally, and the accumulation of inflammatory cells was quantified by bronchoalveolar lavage. Pulmonary injury, manifested by increased capillary permeability, developed progressively during exposure to hyperoxia and was associated with significant augmentation of the procoagulant activity of alveolar macrophages early in the disease. This increase preceded the accumulation of polymorphonuclear leukocytes. Alveolar macrophage procoagulant activity had functional characteristics consistent with tissue factor. These studies provide evidence of early alveolar macrophage activation in acute hyperoxic lung injury in rats and suggest a role for procoagulant activity in the development of interstitial fibrin deposition.
Similar articles
-
NTP Toxicology and Carcinogenesis Studies of Talc (CAS No. 14807-96-6)(Non-Asbestiform) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).Natl Toxicol Program Tech Rep Ser. 1993 Sep;421:1-287. Natl Toxicol Program Tech Rep Ser. 1993. PMID: 12616290
-
[Procoagulant activity of alveolar macrophages in bleomycin-induced lung fibrosis in rats].Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Jun;28(6):867-74. Nihon Kyobu Shikkan Gakkai Zasshi. 1990. PMID: 1699018 Japanese.
-
Coagulation, fibrinolysis, and fibrin deposition in acute lung injury.Crit Care Med. 2003 Apr;31(4 Suppl):S213-20. doi: 10.1097/01.CCM.0000057846.21303.AB. Crit Care Med. 2003. PMID: 12682443 Review.
-
The role of leukocytes in the pathogenesis of fibrin deposition in bovine acute lung injury.Am J Pathol. 1991 May;138(5):1191-8. Am J Pathol. 1991. PMID: 2024707 Free PMC article.
-
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases.Thromb Haemost. 2008 Mar;99(3):494-501. doi: 10.1160/TH07-11-0666. Thromb Haemost. 2008. PMID: 18327397 Review.
Cited by
-
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries.Antioxidants (Basel). 2023 Feb 21;12(3):548. doi: 10.3390/antiox12030548. Antioxidants (Basel). 2023. PMID: 36978796 Free PMC article. Review.
-
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway.Sci Rep. 2021 Mar 29;11(1):7052. doi: 10.1038/s41598-021-86002-x. Sci Rep. 2021. PMID: 33782412 Free PMC article.
-
The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases.Antioxid Redox Signal. 2019 Nov 1;31(13):954-993. doi: 10.1089/ars.2019.7818. Epub 2019 Jul 11. Antioxid Redox Signal. 2019. PMID: 31184204 Free PMC article. Review.
-
Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide.Am J Pathol. 1993 Jul;143(1):76-84. Am J Pathol. 1993. PMID: 8317556 Free PMC article.
-
Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.Proc Natl Acad Sci U S A. 1989 Apr;86(8):2839-43. doi: 10.1073/pnas.86.8.2839. Proc Natl Acad Sci U S A. 1989. PMID: 2704749 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources