Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar 22:2021:8843179.
doi: 10.1155/2021/8843179. eCollection 2021.

Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts

Daniella Da Silva  1 , Anine Crous  1 , Heidi Abrahamse  1
Affiliations
Review

Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts

Daniella Da Silva et al. Stem Cells Int. .

Abstract

Osteoporosis is regarded as the most common chronic metabolic bone condition in humans. In osteoporosis, bone mesenchymal stem cells (MSCs) have reduced cellular function. Regenerative medicine using adipose-derived stem cell (ADSC) transplantation can promote the growth and strength of new bones, improve bone stability, and reduce the risk of fractures. Various methods have been attempted to differentiate ADSCs to functioning specialized cells for prospective clinical application. However, commonly used therapies have resulted in damage to the donor site and morbidity, immune reactions, carcinogenic generation, and postoperative difficulties. Photobiomodulation (PBM) improves ADSC differentiation and proliferation along with reducing clinical difficulties such as treatment failures to common drug therapies and late initiation of treatment. PBM is a noninvasive, nonthermal treatment that encourages cells to produce more energy and to undergo self-repair by using visible green and red and invisible near-infrared (NIR) radiation. The use of PBM for ADSC proliferation and differentiation has been widely studied with multiple outcomes observed due to laser fluence and wavelength dependence. In this article, the potential for differentiating ADSCs into osteoblasts and the various methods used, including biological induction, chemical induction, and PBM, will be addressed. Likewise, the optimal laser parameters that could improve the proliferation and differentiation of ADSC, translating into clinical success, will be commented on.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Osteogenic lineage. The process of osteogenic differentiation of MSCs.
Figure 2
Figure 2
Regenerative medicine. The isolation of stem cells from the host through biopsy, which are encouraged to proliferate and differentiate using various growth factors and physical mechanisms. After differentiation, cells are transplanted back into the host.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Akkawi I., Zmerly H. Osteoporosis: current concepts. Joints. 2018;6(2):122–127. doi: 10.1055/s-0038-1660790. - DOI - PMC - PubMed
    1. Li C., Wei G., Gu Q., Wang Q., Tao S., Xu L. Proliferation and differentiation of rat osteoporosis mesenchymal stem cells (MSCs) after telomerase reverse transcriptase (TERT) transfection. Medical Science Monitor. 2015;21:845–854. doi: 10.12659/MSM.893144. - DOI - PMC - PubMed
    1. Mason C., Dunnill P. A brief definition of regenerative medicine. Regenerative Medicine. 2008;3(1):1–5. doi: 10.2217/17460751.3.1.1. - DOI - PubMed
    1. POLAK J. M., Bishop A. E. Stem cells and tissue engineering: past, present, and future. Annals of the New York Academy of Sciences. 2006;1068(1):352–366. doi: 10.1196/annals.1346.001. - DOI - PubMed
    1. Bajek A., Gurtowska N., Olkowska J., Kazmierski L., Maj M., Drewa T. Adipose-derived stem cells as a tool in cell-based therapies. Archivum Immunologiae et Therapiae Experimentalis (Warsz) 2016;64(6):443–454. doi: 10.1007/s00005-016-0394-x. - DOI - PMC - PubMed

LinkOut - more resources

-