Using Green Biosynthesized Lycopene-Coated Selenium Nanoparticles to Rescue Renal Damage in Glycerol-Induced Acute Kidney Injury in Rats
- PMID: 34234429
- PMCID: PMC8254550
- DOI: 10.2147/IJN.S306186
Using Green Biosynthesized Lycopene-Coated Selenium Nanoparticles to Rescue Renal Damage in Glycerol-Induced Acute Kidney Injury in Rats
Abstract
Purpose: Selenium nanoparticles (SeNPs) have recently gained much attention in nanomedicine applications owing to their unique biological properties. Biosynthesis of SeNPs using nutraceuticals as lycopene (LYC) maximizes their stability and bioactivities. In this context, this study aimed to elucidate the renoprotective activity of SeNPs coated with LYC (LYC-SeNPs) in the acute kidney injury (AKI) model.
Methods: Rats were divided into six groups: control, AKI (glycerol-treated), AKI+sodium selenite (Na2SeO3; 0.5 mg/kg), AKI+LYC (10 mg/kg), AKI+LYC-SeNPs (0.5 mg/kg) and treated for 14 days.
Results: Glycerol treatment evoked significant increases in rhabdomyolysis-related markers (creatine kinase and LDH). Furthermore, relative kidney weight, Kim-1, neutrophil gelatinase-associated lipocalin (NGAL), serum urea, and creatinine in the AKI group were elevated. Glycerol-injected rats displayed declines in reduced glutathione level, and superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities, paralleled with downregulations in Nfe2l2 and Hmox-1 expressions and high renal MDA and NO contents. Glycerol-induced renal inflammation was evident by rises in TNF-α, IL-1β, IL-6, and upregulated Nos2 expression. Also, apoptotic (elevated caspase-3, Bax, and cytochrome-c with lowered Bcl-2) and necroptotic (elevated Pipk3 expression) changes were reported in damaged renal tissue. Co-treatment with Na2SeO3, LYC, or LYC-SeNPs restored the biochemical, molecular, and histological alterations in AKI. In comparison with Na2SeO3 or LYC treatment, LYC-SeNPs had the best nephroprotective profile.
Conclusion: Our findings authentically revealed that LYC-SeNPs co-administration could be a prospective candidate against AKI-mediated renal damage via antioxidant, anti-inflammatory, anti-apoptotic and anti-necroptotic activities.
Keywords: acute kidney injury; apoptosis; inflammation; lycopene; necroptosis; oxidative stress; selenium nanoparticles.
© 2021 Al-Brakati et al.
Conflict of interest statement
The authors declare no conflicts of interest in this work.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0004.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0005.gif)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0006.gif)
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0007.gif)
![Figure 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0008.gif)
![Figure 9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8254550/bin/IJN-16-4335-g0009.gif)
Similar articles
-
Effects of selenium nanoparticles produced by Lactobacillus acidophilus HN23 on lipid deposition in WRL68 cells.Bioorg Chem. 2024 Apr;145:107165. doi: 10.1016/j.bioorg.2024.107165. Epub 2024 Feb 7. Bioorg Chem. 2024. PMID: 38367427 Review.
-
Nephroprotective Efficacy of Echinops spinosus against a Glycerol-Induced Acute Kidney Injury Model.ACS Omega. 2023 Oct 23;8(44):41865-41875. doi: 10.1021/acsomega.3c06792. eCollection 2023 Nov 7. ACS Omega. 2023. PMID: 37969968 Free PMC article.
-
Modulation of inflammatory, oxidative, and apoptotic stresses mediates the renoprotective effect of daidzein against glycerol-induced acute kidney injury in rats.Environ Sci Pollut Res Int. 2023 Dec;30(56):119016-119033. doi: 10.1007/s11356-023-30461-4. Epub 2023 Nov 3. Environ Sci Pollut Res Int. 2023. PMID: 37919499
-
Application of Selenium Nanoparticles in Localized Drug Targeting for Cancer Therapy.Anticancer Agents Med Chem. 2022 Aug 4;22(15):2715-2725. doi: 10.2174/1871520622666220215122756. Anticancer Agents Med Chem. 2022. PMID: 35168523 Review.
-
Nephroprotective Role of Selenium Nanoparticles Against Glycerol-Induced Acute Kidney Injury in Rats.Biol Trace Elem Res. 2020 Apr;194(2):444-454. doi: 10.1007/s12011-019-01793-5. Epub 2019 Jul 1. Biol Trace Elem Res. 2020. PMID: 31264127
Cited by
-
Renoprotective effect of thymoquinone against rhabdomyolysis-induced acute kidney injury in the rat model.Iran J Basic Med Sci. 2024;27(5):552-559. doi: 10.22038/IJBMS.2023.72797.15838. Iran J Basic Med Sci. 2024. PMID: 38629092 Free PMC article.
-
Selenomethionine Alleviates Deoxynivalenol-Induced Oxidative Injury in Porcine Intestinal Epithelial Cells Independent of MAPK Pathway Regulation.Antioxidants (Basel). 2024 Mar 16;13(3):356. doi: 10.3390/antiox13030356. Antioxidants (Basel). 2024. PMID: 38539889 Free PMC article.
-
Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and Cell Apoptosis.Anticancer Agents Med Chem. 2024;24(6):443-453. doi: 10.2174/0118715206274530231213104519. Anticancer Agents Med Chem. 2024. PMID: 38204261
-
Selenium Nanoparticles: Green Synthesis and Biomedical Application.Molecules. 2023 Dec 15;28(24):8125. doi: 10.3390/molecules28248125. Molecules. 2023. PMID: 38138613 Free PMC article. Review.
-
The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats.Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):4365-4379. doi: 10.1007/s00210-023-02887-7. Epub 2023 Dec 15. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38099937 Free PMC article.
References
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous