Strategies for Browning Agent Delivery

doi:10.1007/s11095-021-03081-1

Review

. 2021 Aug;38(8):1327-1334.

doi: 10.1007/s11095-021-03081-1. Epub 2021 Aug 16.

Strategies for Browning Agent Delivery

Wentao Zhang¹, Tao Sheng¹, Zhen Gu^{2

3

4

5}, Yuqi Zhang⁶

Affiliations

¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
² College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. guzhen@zju.edu.cn.
³ Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. guzhen@zju.edu.cn.
⁴ Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 311121, China. guzhen@zju.edu.cn.
⁵ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. guzhen@zju.edu.cn.
⁶ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yqzhang21@zju.edu.cn.

PMID: 34398404
DOI: 10.1007/s11095-021-03081-1

Review

Strategies for Browning Agent Delivery

Wentao Zhang et al. Pharm Res. 2021 Aug.

. 2021 Aug;38(8):1327-1334.

doi: 10.1007/s11095-021-03081-1. Epub 2021 Aug 16.

Authors

Wentao Zhang¹, Tao Sheng¹, Zhen Gu^{2

3

4

5}, Yuqi Zhang⁶

Affiliations

¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
² College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. guzhen@zju.edu.cn.
³ Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. guzhen@zju.edu.cn.
⁴ Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 311121, China. guzhen@zju.edu.cn.
⁵ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. guzhen@zju.edu.cn.
⁶ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yqzhang21@zju.edu.cn.

PMID: 34398404
DOI: 10.1007/s11095-021-03081-1

Abstract

Obesity expands as a global climbing epidemic that is often correlated to cardiovascular diseases and endocrine disorders. Converting white adipocytes to brown adipocytes for enhanced energy expenditure has recently emerged as a promising anti-obesity treatment. However, the conventional approaches to apply browning agents systematically suffer from off-target effects, multiple dosage requirements, and poor patient compliance. To date, various delivery strategies have been reported to deliver browning agents for obesity treatment in a safer and more controllable manner. This review will discuss the latest designs in browning agent delivery systems with a focus on nanomedicines and transdermal patches.

Keywords: adipocyte; browning agent; drug delivery; nanoparticle; transdermal patch.

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References

1. GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. - DOI
1. Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635–43. - PubMed - DOI - PMC
1. Araújo J, Cai J, Stevens J. Prevalence of optimal metabolic health in American adults: National Health and nutrition examination survey 2009–2016. Metab Syndr Relat Disord. 2018;17(1):46–52. - PubMed - DOI - PMC
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1. Ogden CL, Yanovski SZ, Carroll MD, Flegal KM. The epidemiology of obesity. Gastroenterology. 2007;132(6):2087–102. - PubMed - DOI - PMC

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[1] GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. - DOI

[2] GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. - DOI

[3] Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635–43. - PubMed - DOI - PMC

[4] Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635–43. - PubMed - DOI - PMC

[5] Araújo J, Cai J, Stevens J. Prevalence of optimal metabolic health in American adults: National Health and nutrition examination survey 2009–2016. Metab Syndr Relat Disord. 2018;17(1):46–52. - PubMed - DOI - PMC

[6] Araújo J, Cai J, Stevens J. Prevalence of optimal metabolic health in American adults: National Health and nutrition examination survey 2009–2016. Metab Syndr Relat Disord. 2018;17(1):46–52. - PubMed - DOI - PMC

[7] Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab. 2004;89(6):2583–9. - PubMed - DOI - PMC

[8] Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab. 2004;89(6):2583–9. - PubMed - DOI - PMC

[9] Ogden CL, Yanovski SZ, Carroll MD, Flegal KM. The epidemiology of obesity. Gastroenterology. 2007;132(6):2087–102. - PubMed - DOI - PMC

[10] Ogden CL, Yanovski SZ, Carroll MD, Flegal KM. The epidemiology of obesity. Gastroenterology. 2007;132(6):2087–102. - PubMed - DOI - PMC

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Strategies for Browning Agent Delivery

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Strategies for Browning Agent Delivery

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