Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

doi:10.3390/ijerph19031742

. 2022 Feb 3;19(3):1742.

doi: 10.3390/ijerph19031742.

Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Marvin E Langston^{1

2}, Heidi E Brown², Charles F Lynch³, Denise J Roe², Leslie K Dennis^{2

3}

Affiliations

¹ Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
² Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
³ Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

PMID: 35162766
PMCID: PMC8835255
DOI: 10.3390/ijerph19031742

Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Marvin E Langston et al. Int J Environ Res Public Health. 2022.

. 2022 Feb 3;19(3):1742.

doi: 10.3390/ijerph19031742.

Authors

Marvin E Langston^{1

2}, Heidi E Brown², Charles F Lynch³, Denise J Roe², Leslie K Dennis^{2

3}

Affiliations

¹ Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
² Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
³ Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

PMID: 35162766
PMCID: PMC8835255
DOI: 10.3390/ijerph19031742

Abstract

Intermittent sun exposure is the major environmental risk factor for cutaneous melanoma (CM). Cumulative sun exposure and other environmental agents, such as environmental arsenic exposure, have not shown consistent associations. Ambient ultraviolet radiation (UVR) was used to measure individual total sun exposure as this is thought to be less prone to misclassification and recall bias. Data were analyzed from 1096 CM cases and 1033 controls in the Iowa Study of Skin Cancer and Its Causes, a population-based, case-control study. Self-reported residential histories were linked to satellite-derived ambient UVR, spatially derived environmental soil arsenic concentration, and drinking water arsenic concentrations. In men and women, ambient UVR during childhood and adolescence was not associated with CM but was positively associated during adulthood. Lifetime ambient UVR was positively associated with CM in men (OR for highest vs. lowest quartile: 6.09, 95% confidence interval (CI) 2.21-16.8), but this association was not as strong among women (OR for highest vs. lowest quartile: 2.15, 95% CI 0.84-5.54). No association was detected for environmental soil or drinking water arsenic concentrations and CM. Our findings suggest that lifetime and adulthood sun exposures may be important risk factors for CM.

Keywords: arsenic; melanoma; sun exposure; ultraviolet radiation.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. El Ghissassi F., Baan R., Straif K., Grosse Y., Secretan B., Bouvard V., Benbrahim-Tallaa L., Guha N., Freeman C., Galichet L., et al. A review of human carcinogens—Part d: Radiation. Lancet Oncol. 2009;10:751–752. doi: 10.1016/S1470-2045(09)70213-X. - DOI - PubMed
1. Olsen C.M., Carroll H.J., Whiteman D.C. Estimating the attributable fraction for melanoma: A meta-analysis of pigmentary characteristics and freckling. Int. J. Cancer. 2010;127:2430–2445. doi: 10.1002/ijc.25243. - DOI - PubMed
1. Chang Y., Barrett J.H., Bishop D.T., Armstrong B.K., Bataille V., Bergman W., Berwick M., Bracci P.M., Elwood J.M., Ernstoff M.S., et al. Sun Exposure and Melanoma Risk at Different Latitudes: A Pooled Analysis of 5700 Cases and 7216 Controls. Int. J. Epidemiol. 2009;38:814–830. doi: 10.1093/ije/dyp166. - DOI - PMC - PubMed

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[1] Howlader N., Noone A.M., Krapcho M., Miller D., Brest A., Yu M., Ruhl J., Tatalovich Z., Mariotto A., Lewis D.R., et al., editors. SEER Cancer Statistics Review, 1975–2017. National Cancer Institute; Bethesda, MD, USA: 2019. [(accessed on 1 January 2021)]. Available online: https://seer.cancer.gov/csr/1975_2017/

[2] Howlader N., Noone A.M., Krapcho M., Miller D., Brest A., Yu M., Ruhl J., Tatalovich Z., Mariotto A., Lewis D.R., et al., editors. SEER Cancer Statistics Review, 1975–2017. National Cancer Institute; Bethesda, MD, USA: 2019. [(accessed on 1 January 2021)]. Available online: https://seer.cancer.gov/csr/1975_2017/

[3] Armstrong B.K., Kricker A. The epidemiology of UV induced skin cancer. J. Photochem. Photobiol. B Biol. 2001;63:8–18. doi: 10.1016/S1011-1344(01)00198-1. - DOI - PubMed

[4] Armstrong B.K., Kricker A. The epidemiology of UV induced skin cancer. J. Photochem. Photobiol. B Biol. 2001;63:8–18. doi: 10.1016/S1011-1344(01)00198-1. - DOI - PubMed

[5] El Ghissassi F., Baan R., Straif K., Grosse Y., Secretan B., Bouvard V., Benbrahim-Tallaa L., Guha N., Freeman C., Galichet L., et al. A review of human carcinogens—Part d: Radiation. Lancet Oncol. 2009;10:751–752. doi: 10.1016/S1470-2045(09)70213-X. - DOI - PubMed

[6] El Ghissassi F., Baan R., Straif K., Grosse Y., Secretan B., Bouvard V., Benbrahim-Tallaa L., Guha N., Freeman C., Galichet L., et al. A review of human carcinogens—Part d: Radiation. Lancet Oncol. 2009;10:751–752. doi: 10.1016/S1470-2045(09)70213-X. - DOI - PubMed

[7] Olsen C.M., Carroll H.J., Whiteman D.C. Estimating the attributable fraction for melanoma: A meta-analysis of pigmentary characteristics and freckling. Int. J. Cancer. 2010;127:2430–2445. doi: 10.1002/ijc.25243. - DOI - PubMed

[8] Olsen C.M., Carroll H.J., Whiteman D.C. Estimating the attributable fraction for melanoma: A meta-analysis of pigmentary characteristics and freckling. Int. J. Cancer. 2010;127:2430–2445. doi: 10.1002/ijc.25243. - DOI - PubMed

[9] Chang Y., Barrett J.H., Bishop D.T., Armstrong B.K., Bataille V., Bergman W., Berwick M., Bracci P.M., Elwood J.M., Ernstoff M.S., et al. Sun Exposure and Melanoma Risk at Different Latitudes: A Pooled Analysis of 5700 Cases and 7216 Controls. Int. J. Epidemiol. 2009;38:814–830. doi: 10.1093/ije/dyp166. - DOI - PMC - PubMed

[10] Chang Y., Barrett J.H., Bishop D.T., Armstrong B.K., Bataille V., Bergman W., Berwick M., Bracci P.M., Elwood J.M., Ernstoff M.S., et al. Sun Exposure and Melanoma Risk at Different Latitudes: A Pooled Analysis of 5700 Cases and 7216 Controls. Int. J. Epidemiol. 2009;38:814–830. doi: 10.1093/ije/dyp166. - DOI - PMC - PubMed

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Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Affiliations

Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Authors

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Conflict of interest statement

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Abstract

Conflict of interest statement

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