Effects of green tea on prostate carcinogenesis in rat models and a human prostate cancer xenograft model
- PMID: 35485427
- PMCID: PMC9246968
- DOI: 10.1002/pros.24364
Effects of green tea on prostate carcinogenesis in rat models and a human prostate cancer xenograft model
Abstract
Background: There is evidence to suggest that green tea soy may have protective effects against prostate cancer, but there are several epidemiologic and clinical studies that did not identify such an effect. We tested the notion of protective effects in a rat model of prostate carcinogenesis that has been predictive of the effects of selenium and vitamin E in randomized clinical trials and a human prostate cancer xenograft model in nude mice and rat prostate tumor cells transplanted in immune-competent syngeneic animals.
Methods: Prostate cancer was induced in rats with methylnitrosourea and testosterone and tumor incidence was determined. Subcutaneous tumor growth was measured resulting from injected cells isolated from rat prostate cancers grafted in syngeneic animals and from the prostate-specific antigen (PSA)-producing human prostate cancer PC346 xenografted in nude mice. Brewed decaffeinated green tea infusion or caffeinated green tea extract and the same 300 mg/ml concentration of caffeine were provided in drinking water of the rats and nude mice.
Results: Caffeinated green tea extract and caffeine provided in drinking water did not modify the induction of prostate cancer in the rat model compared with control rats. The same drinking water treatments also did not affect the growth and PSA production of PC346 human prostate cancer xenografts in nude mice and the growth of two transplantable rat prostate cancer tumor lines in Wistar Firth rats. Brewed green tea infusion as drinking water did also not affect tumor growth in these xeno- and allograft models.
Conclusion: These animal studies with drinking water exposure to green tea and caffeine do not support the idea that green tea is protective against prostate cancer.
Keywords: caffeine; cancer induction model; green tea; prostate cancer; tumor growth models.
© 2022 Wiley Periodicals LLC.
Conflict of interest statement
CONFLICT OF INTEREST
The authors declare that there are no potential conflicts of interest.
Similar articles
-
Sodium arsenite does not affect prostate carcinogenesis in a chemically-hormonally-induced rat model.Toxicology. 2022 May 30;474:153212. doi: 10.1016/j.tox.2022.153212. Epub 2022 May 20. Toxicology. 2022. PMID: 35598691
-
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.Carcinogenesis. 2008 Aug;29(8):1581-6. doi: 10.1093/carcin/bgm237. Epub 2008 Jul 16. Carcinogenesis. 2008. PMID: 18635525 Free PMC article.
-
Molecular targets for green tea in prostate cancer prevention.J Nutr. 2003 Jul;133(7 Suppl):2417S-2424S. doi: 10.1093/jn/133.7.2417S. J Nutr. 2003. PMID: 12840218 Review.
-
Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase.Cancer Res. 1999 May 1;59(9):2115-20. Cancer Res. 1999. PMID: 10232597
-
The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea.Proc Soc Exp Biol Med. 1999 Apr;220(4):244-8. doi: 10.1046/j.1525-1373.1999.d01-42.x. Proc Soc Exp Biol Med. 1999. PMID: 10202397 Review.
Cited by
-
Novel Insights into the Role of the Antioxidants in Prostate Pathology.Antioxidants (Basel). 2023 Jan 27;12(2):289. doi: 10.3390/antiox12020289. Antioxidants (Basel). 2023. PMID: 36829848 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous